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Publications

Browse FSI scholarship on geopolitics, global health, energy, cybersecurity and more.

Featured Publications

Everything Counts: Building a Control Regime for Nonstrategic Nuclear Warheads in Europe

Building a Control Regime for Nonstrategic Nuclear Warheads in Europe

A new report led by Rose Gottemoeller on non-strategic nuclear warhead policies in Europe, particulary in light of Russia's changing status in the global nuclear community.
3D mockup cover of APARC's volume 'South Korea's Democracy in Crisis'

South Korea’s Democracy in Crisis

A close look at what is driving illiberalism and democratic delcine in today’s Korea, including political polarization, politicization of institutions, societal inequality, education, and social media.
System Error book cover and authors

System Error: Where Big Tech Went Wrong and How We Can Reboot

A forward-thinking manifesto which reveals how big tech’s obsession with optimization and efficiency has sacrificed fundamental human values.

Publications

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Douglas K. Owens
Journal Articles

Impact of Treatment Duration on Mortality Among Veterans with Opioid Use Disorder in The United States Veterans Health Administration

Jack Ching, Douglas K. Owens, Jodie A. Trafton , Jeremy Goldhaber-Fiebert, Joshua Salomon
Wiley Online Library, 2021 May 17, 2021
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Case Studies

Evidence-Based Practice for Public Health Emergency Preparedness and Response

Jeremy Goldhaber-Fiebert, Douglas K. Owens, et al.
National Academies of Sciences, Engineering and Medicine, 2020 July 14, 2020

Yet there has been no national-level, comprehensive review of the evidence for public health emergency preparedness and response (PHEPR) practices. Recognizing this deficiency, the Centers for Disease Control and Prevention (CDC) went to the National Academies of Sciences, Engineering and Medicine three years ago and asked them to convene a national panel of public health experts to review the evidence for emergency preparedness and response. The committee members included Stanford Health Policy Director Douglas K.

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Journal Articles

Cost-Effectiveness of Transitional Care Services After Hospitalization With Heart Failure

Manuel R. Blum, Henning Øien, Harris Carmichael, Paul A. Heidenreich, Douglas K. Owens, Jeremy Goldhaber-Fiebert
Annals of Internal Medicine , 2020 February 18, 2020

Background:

Patients with heart failure (HF) discharged from the hospital are at high risk for death and rehospitalization. Transitional care service interventions attempt to mitigate these risks.

Results of Base-Case Analysis:

All 3 transitional care interventions examined were more costly and effective than standard care, with NHVs dominating the other 2 interventions. Compared with standard care, NHVs increased QALYs (2.49 vs. 2.25) and costs ($81 327 vs. $76 705), resulting in an ICER of $19 570 per QALY gained.

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Journal Articles

Cost Effectiveness of Radiation and Chemotherapy for High-Risk Low Grade Glioma

Eran Bendavid, Eran Bendavid, Douglas K. Owens, Yushen Qian, Satoshi Muruyama
2018 August 1, 2018

The standard of care treatment for maximally resected, high risk (≥ 40 years old or sub-totally resected) low grade glioma (LGG) patients was established by RTOG 9802, which showed an overall survival (OS) of 13.3 years for patients treated with radiotherapy (RT) + PCV (procarbazine, lomustine [CCNU], vincristine) chemotherapy compared to 7.8 years for RT alone. In the era of value-based health care, cost-effectiveness analyses (CEA) have the potential to inform coverage decisions and patient care.

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Journal Articles

Poverty and Community-Acquired Antimicrobial Resistance with Extended-Spectrum β-Lactamase–Producing Organisms, Hyderabad, India

Nagamani Kammili, Jyothi Lakshmi, Anlu Xing, Afia Khan, Manisha Rani, Prasanthi Kolli, Anlu Xing, Douglas K. Owens
Emerging Infectious Diseases Journal, 2018 August 1, 2018

The decreasing effectiveness of antimicrobial agents is a global public health threat, yet risk factors for community-acquired antimicrobial resistance (CA-AMR) in low-income settings have not been clearly elucidated. Our aim was to identify risk factors for CA-AMR with extended-spectrum β-lactamase (ESBL)–producing organisms among urban-dwelling women in India. We collected microbiological and survey data in an observational study of primigravidae women in a public hospital in Hyderabad, India.

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Journal Articles

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force, Kristen Bibbins-Domingo, David C. Grossman, Susan J. Curry, Karina W. Davidson, John W. Epling, Jr., Francisco A. R. Garcia, Matthew W. Gillman, Diane M. Harper, Alex R. Kemper, Douglas K. Owens, William R. Phillips, Maureen G. Phibbs, Michael P. Pignone, Albert L. Siu
Journal of the American Medical Association (JAMA), 2016 December 15, 2016

Importance  Colorectal cancer is the second leading cause of cancer death in the United States. In 2016, an estimated 134 000 persons will be diagnosed with the disease, and about 49 000 will die from it. Colorectal cancer is most frequently diagnosed among adults aged 65 to 74 years; the median age at death from colorectal cancer is 68 years.

Objective  To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on screening for colorectal cancer.

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Journal Articles

Breast density notification legislation and breast cancer stage at diagnosis: early evidence from the SEER registry

Ilana Richman, Steven M. Asch, Eran Bendavid, Jay Bhattacharya, Douglas K. Owens
Journal of General Internal Medicine, 2016 November 16, 2016

Background

Twenty-eight states have passed breast density notification laws, which require physicians to inform women of a finding of dense breasts on mammography.

Objective

To evaluate changes in breast cancer stage at diagnosis after enactment of breast density notification legislation.

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Journal Articles

Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement

Kirsten Bibbins-Domingo, David C. Grossman, Susan J. Curry, Karina W. Davidson, John W. Epling, Francisco A. R. Garcia, Matthew W. Gillman, Alex R. Kemper, Alex H. Krist, Ann E. Kurth, Seth Landefeld, Michael L. LeFevre, Carol M. Mangione, William R. Phillips, Douglas K. Owens, Maureen G. Phibbs, Michael P. Pignone
Journal of the American Medical Association (JAMA), 2016 November 15, 2016

Importance:

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States, accounting for 1 of every 3 deaths among adults.

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Journal Articles

Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement

The US Preventive Services Task Force, Kirsten Bibbins-Domingo, David C. Grossman, Susan J. Curry, Karina W. Davidson, John W. Epling, Jr., Francisco A. R. Garcia, Matthew W. Gillman, Alex R. Kemper, Alex H. Krist, Ann E. Kurth, Seth Landefeld, Michael LeFevre, Carol M. Mangione, Douglas K. Owens, Williams R. Phillips, Maureen G. Phibbs, Michael P. Pignone, Albert L. Siu
Journal of the American Medical Association (JAMA), 2016 August 9, 2016

Importance  Elevations in levels of total, low-density lipoprotein, and non–high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults.

Objective  To update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults.

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Journal Articles

Cost-Effectiveness of HIV Preexposure Prophylaxis for People Who Inject Drugs in the United States

Cora L. Bernard, Margaret L. Brandeau, Keith Humphreys, Eran Bendavid, Mark Holodniy, Christopher Weyant, Douglas K. Owens, Jeremy Goldhaber-Fiebert
Annals of Internal Medicine, 2016 July 5, 2016

Background: The total population health benefits and costs of HIV preexposure prophylaxis (PrEP) for people who inject drugs (PWID) in the United States are unclear.

Objective: To evaluate the cost-effectiveness and optimal delivery conditions of PrEP for PWID.

Design: Empirically calibrated dynamic compartmental model.

Data Sources: Published literature and expert opinion.

Target Population: Adult U.S. PWID.

Time Horizon: 20 years and lifetime.

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Journal Articles

Cost-Effectiveness of Percutaneous Closure of the Left Atrial Appendage in Atrial Fibrillation Based on Results From PROTECT AF Versus PREVAIL

James V. Freeman, David W. Hutton, Geoffrey D. Barnes, Ruo P. Zhu, Douglas K. Owens, Alan M. Garber, Alan S. Go, Mark A. Hlatky, Paul A. Heidenreich, Paul J. Wang, Amin Al-Ahmad, Mintu P. Turakhia
Circulation: Arrhythmia and Electrophysiology, 2016 June 15, 2016

Background—Randomized trials of left atrial appendage (LAA) closure with the Watchman device have shown varying results, and its cost effectiveness compared with anticoagulation has not been evaluated using all available contemporary trial data.

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Journal Articles

Evaluating the Productivity of VA, NIH, and AHRQ Health Services Research Center Development Awardees

John W. Finney, Erin O. Amundson, Xiaoyu Bi, Michael A. Cucciare, Seth A. Eisen, Andrea K. Finlay, Max A. Halvorson, Ko Hayashi, Douglas K. Owens, Natalya C. Maisel, Christine Timko, Julie C. Weitlauf, Ruth C. Cronkite
Academic Medicine, 2015 November 13, 2015
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Journal Articles

Cost-Effectiveness of Adding Cardiac Resynchronization Therapy to an Implantable Cardioverter-Defibrillator Among Patients With Mild Heart Failure

Christopher Y. Woo, Erika J. Strandberg, Michelle D. Schmiegelow, Allison L. Pitt, Mark A. Hlatky, Douglas K. Owens, Jeremy D. Goldhaber-Fiebert
2015 August 25, 2015

new study by Stanford researchers indicates adding cardiac resynchronization therapy to an implanted cardioverter-defibr

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Journal Articles

Risk of Cardiovascular Events Associated With Current Exposure to HIV Antiretroviral Therapies in a US Veteran Population

Manisha Desai, Vilija Joyce, Eran Bendavid, Richard A. Olshen, Mark A. Hlatky, Adam Chow, Mark Holodniy, Paul Barnett, Douglas K. Owens
Clinical Infectious Diseases, 2015 August 1, 2015

Background. To characterize the association of antiretroviral drug combinations on risk of cardiovascular events.

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Journal Articles

Cost-Effectiveness of Helicopter Versus Ground Emergency Medical Services for Trauma Scene Transport in the United States

Mucio Kit Delgado, Kristan L. Staudenmayer, Nancy Ewen Wang, David A. Spain, Sharada Weir, Douglas K. Owens, Jeremy Goldhaber-Fiebert
Annals of Emergency Medicine, 2013 December 31, 2013
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Journal Articles

Screening and Rapid Molecular Diagnosis of Tuberculosis in Prisons in Russia and Eastern Europe: A Cost-Effectiveness Analysis

DE Winetsky, DM Negoescu, EH DeMarchis, O Almukhamedova, A Dooronbekova, D Pulatov, N Vezhnina, Douglas Owens, Jeremy Goldhaber-Fiebert
PLoS Medicine, 2012 December 31, 2012

Prisons of the former Soviet Union (FSU) have high rates of multidrug-resistant tuberculosis (MDR-TB) and are thought to drive general population tuberculosis (TB) epidemics. Effective prison case detection, though employing more expensive technologies, may reduce long-term treatment costs and slow MDR-TB transmission.

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Journal Articles

Screening and diagnosis of tuberculosis in prisons in Russia and Eastern Europe: a cost-effectiveness analysis

Winetsky DE, Negoescu DM, Almukhamedova O, DeMarchis E, Dooronbekova A, Pulatov D, Vezhnina N, Zhussupov B, Douglas K. Owens, Jeremy Goldhaber-Fiebert
PLoS Medicine, 2012 December 31, 2012

Background: Prisons of the former Soviet Union (FSU) have high rates of multidrug-resistant tuberculosis (MDR-TB) and are thought to drive general population tuberculosis (TB) epidemics. Effective prison case detection, though employing more expensive technologies, may reduce long-term treatment costs and slow MDR-TB transmission.

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Journal Articles

Balancing immunological benefits and cardiovascular risks of antiretroviral therapy: When is immediate treatment optimal?

Negoescu, D.M., Douglas K. Owens, Margaret L. Brandeau, Eran Bendavid
Clinical Infectious Diseases, 2012 December 31, 2012
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Journal Articles

New Protease Inhibitors for the Treatment of Chronic Hepatitis C: A Cost-Effectiveness Analysis

Shan Liu, Lauren E. Cipriano, Mark Holodniy, Douglas K. Owens, Jeremy Goldhaber-Fiebert
Annals of Internal Medicine, 2012 February 21, 2012

Background: Chronic hepatitis C virus is difficult to treat and affects approximately 3 million Americans. Protease inhibitors increase the effectiveness of standard therapy, but they are costly. A genetic assay may identify patients most likely to benefit from this treatment advance.

Objective: To assess the cost-effectiveness of new protease inhibitors and an interleukin (IL)–28B genotyping assay for treating chronic hepatitis C virus.

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Journal Articles

Improving practice guidelines with patient-specific recommendations

Douglas Owens
Annals of Internal Medicine, 2011 December 31, 2011

Clinical practice guidelines aim to help providers make decisions that optimize patient care (1). Both developers and users of guidelines understand that guidelines could be improved by tailoring the recommendations to the specific circumstances of an individual patient. Tailored guideline recommendations may improve health outcomes when a group of patients can be divided into subgroups in which the tailored recommendations would increase benefits, reduce harms, or save costs relative to more generic recommendations.

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Journal Articles

Determinants of the cost of health services used by veterans with HIV

Barnett PG, Chow A, Vilija Joyce, Bayoumi AM, Griffin SC, Nosyk B, Mark Holodniy, Brown ST, Sculpher M, Anis AH, Douglas K. Owens
Medical Care, 2011 December 31, 2011

BACKGROUND:

The effect of adherence, treatment failure, and comorbidities on the cost of HIV care is not well understood.

OBJECTIVE:

To characterize the cost of HIV care including combination antiretroviral treatment (ART).

RESEARCH DESIGN:

Observational study of administrative data.

SUBJECTS:

Total 1896 randomly selected HIV-infected patients and 288 trial participants with multidrug-resistant HIV seen at the US Veterans Health Administration (VHA).

MEASURES:

Comorbidities, cost, pharmacy, and laboratory data.

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Journal Articles

The cost-effectiveness of symptom-based testing and routine screening for acute HIV infection in men who have sex with men in the USA

Juusola JL, Margaret Brandeau, Long EF, Douglas K. Owens, Eran Bendavid
AIDS, 2011 December 31, 2011

OBJECTIVE:

Acute HIV infection often causes influenza-like illness (ILI) and is associated with high infectivity. We estimated the effectiveness and cost-effectiveness of strategies to identify and treat acute HIV infection in men who have sex with men (MSM) in the USA.

DESIGN:

Dynamic model of HIV transmission and progression.

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