Governance

FSI's research on the origins, character and consequences of government institutions spans continents and academic disciplines. The institute’s senior fellows and their colleagues across Stanford examine the principles of public administration and implementation. Their work focuses on how maternal health care is delivered in rural China, how public action can create wealth and eliminate poverty, and why U.S. immigration reform keeps stalling. 

FSI’s work includes comparative studies of how institutions help resolve policy and societal issues. Scholars aim to clearly define and make sense of the rule of law, examining how it is invoked and applied around the world. 

FSI researchers also investigate government services – trying to understand and measure how they work, whom they serve and how good they are. They assess energy services aimed at helping the poorest people around the world and explore public opinion on torture policies. The Children in Crisis project addresses how child health interventions interact with political reform. Specific research on governance, organizations and security capitalizes on FSI's longstanding interests and looks at how governance and organizational issues affect a nation’s ability to address security and international cooperation.

Note:  The Nov. 3rd opening lecture and reception is now full. We are unable to accept further RSVPs.

This conference will look at modern revolution as a historical script invented in the course of the seventeenth and eighteenth centuries and then elaborated and improvised upon in the nineteenth and twentieth centuries. Rather than asking which is the first modern revolution, or what stages all revolutions may (have to) go through, we will examine revolution as a way of defining and acting upon a particular situation, a narrative frame that political actors explicitly adopted and extended as giving meaning to their goals and strategic choices. To call oneself a revolutionary after the eighteenth century, in other words (or a counter-revolutionary too, for that matter), was to embrace a genealogy and script for action that could be changed or improvised upon, but was necessarily accepted before it could be adjusted or extended in a new context. The aim of the conference will be to see the extent to which modern revolutions can be analyzed and interpreted in this way as so many variations on a common theme. From this perspective, "scripting revolution" would also be about modes of historical writing and narration.

Co-sponsored by the School of Humanities & Sciences, the Division of Literatures, Cultures, and Languages, the Department of History, the Stanford Humanities Center, and the France-Stanford Center

Note:  An RSVP is required to attend the Nov. 3rd opening lecture only.  An RSVP is not required to attend the conference panels on Nov. 4th and Nov. 5th

November 3rd: Bender Room, Green Library (THIS EVENT IS NOW FULL)

November 4th and 5th: Levinthal Hall, Stanford Humanities Center

Caroline Winterer Commentator Stanford University
Pierre Serna Keynote Speaker IHRF/Sorbonne
J.P. Daughton Moderator Stanford University
Tim Harris Panelist Brown University
David Como Panelist Stanford University
Jack Rakove Panelist Stanford University
David Armitage Panelist Harvard University
Katherine McDonough Moderator Stanford University
Keith Baker Panelist Stanford University
Joseph Zizek Panelist University of Auckland
Dan Edelstein Panelist Stanford University
David A. Bell Commentator Princeton University
Kelly Summers Moderator Stanford University
Carla Hesse Panelist UC Berkeley
Guillaume Mazeau Panelist IHRF/Sorbonne
Mary Ashburn Miller Commentator Reed College
Derek Vanderpool Moderator Stanford University
Gareth Stedman Jones Panelist Queen Mary, University of London
Dominica Chang Panelist Lawrence University
Kent Wright Commentator Arizona State University

History Department
Bldg 200, Room 311
Stanford, CA 94305-2024

(650) 723-9475 (650) 725-0597
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William H. Bonsall Professor in History
Professor of History
2017_july_nancy_drottningholm_-_nancy_kollmann.jpg PhD

I became interested in Russia at the height of the Cold War and initially studied Russia and Russian with an eye to the foreign service. History lured me way, especially after spending a junior semester at Leningrad State University in 1970 and having the chance to travel around the Soviet Union a bit. In graduate research and since coming to Stanford in 1982, I have focused on the early modern period (from the fourteenth century through the eighteenth). In almost all my work I have been explored the question of how politics worked in an autocracy. Theoretically I am interested in how early modern states, particularly empires, tried to create, at best, social cohesion and, at least, stability, by ritual, ideology, law and the measured use of violence. My early research focused on structures of power at the Kremlin court and the influence of kinship and marriage in politics and on social values from Muscovy to the Enlightenment (Kinship and Politics: The Making of the Muscovite Political System 1987); these themes encouraged my abiding interest in the roles of women in political ideology and practice. I have written two books on legal culture, one on disputes over honor (By Honor Bound 1999) and one on the practice of the criminal law (Crime and Punishment in Early Modern Russia 2012). Here I’ve contrasted the letter of the law with the workings of local courts, how people used the law, how judges and other officials played roles in the system, how the law was written and interpreted. In all this I’ve tried to place Russia in a comparative context where appropriate, trying to break down clichés of Russia being fundamentally different from European history or unknowable.

My current work goes in several directions. One is a turn to the visual -- I have written several articles on the production and use in Russia of icons, frescos and miniatures as a medium for political communication. I am now finishing up a project on images of Russia produced by foreign engravers in early print publications and maps. The tension in these images between stock tropes of the engraver's trade and eye-witness information, is one fascinating aspect; another is the challenge to assess the impact of text and image on the reader. All in all, I have found that most illustrated works about Russia present a more nuanced understanding than the image of “despotism” that has caught a lot of scholarly attention. Finally, I am interested in how Russia functioned as an empire. I recently published a synthetic history (The Russian Empire 1450-1801 2017) of Russia as a “Eurasian politics of different empire,” and I plan to follow up this theme and return to the practice of the law by studying the implementation of Catherine II’s judicial reforms (1775) in the non-Russian provinces.

Affiliated faculty at The Europe Center
Nancy Kollmann Moderator Stanford University
Lynn Patyk Panelist Dartmouth College
Claudia Verhoeven Panelist Cornell University

Building 200, Room 336
Stanford, CA 94305-2024

(650) 723-3527 (650) 725-0597
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Associate Professor of History
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Amir Weiner's research concerns Soviet history with an emphasis on the interaction between totalitarian politics, ideology, nationality, and society. He is the author of Making Sense of War, Landscaping the Human Garden and numerous articles and edited volumes on the impact of World War II on the Soviet polity, the social history of WWII and Soviet frontier politics. His forthcoming book, The KGB: Ruthless Sword, Imperfect Shield, will be published by Yale University Press in 2021. He is currently working on a collective autobiography of KGB officers titled Coffee with the KGB: Conversations with Soviet Security Officers. Professor Weiner has taught courses on modern Russian history; the Second World War; Totalitarianism; War and Society in Modern Europe; Modern Ukrainian History; and History and Memory.

 

Affiliated faculty at The Europe Center
CV
Amir Weiner Panelist Stanford University
Jonathan Beecher Commentator UC Santa Cruz
Tom Mullaney Moderator Stanford University
Alex Cook Panelist UC Berkeley
David Strand Panelist Dickinson College
Elizabeth McGuire Panelist Harvard University

615 Crothers Way,
Encina Commons, Room 128A
Stanford University
Stanford, CA 94305

(650) 721-4052
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Research Fellow, Hoover Institution
abbas_milani_photo_by_babak_payami.jpg PhD

Abbas Milani is the Hamid and Christina Moghadam Director of Iranian Studies at Stanford University and a visiting professor in the department of political science. In addition, Dr. Milani is a research fellow and co-director of the Iran Democracy Project at the Hoover Institution.

Prior to coming to Stanford, Milani was a professor of history and political science and chair of the department at Notre Dame de Namur University and a research fellow at the Institute of International Studies at the University of California at Berkeley. Milani was an assistant professor in the faculty of law and political science at Tehran University and a member of the board of directors of Tehran University's Center for International Studies from 1979 to 1987. He was a research fellow at the Iranian Center for Social Research from 1977 to 1978 and an assistant professor at the National University of Iran from 1975 to 1977.

Dr. Milani is the author of Eminent Persians: Men and Women Who Made Modern Iran, 1941-1979, (Syracuse University Press, Syracuse, NY, 2 volumes, November, 2008); King of Shadows: Essays on Iran's Encounter with Modernity, Persian text published in the U.S. (Ketab Corp., Spring 2005); Lost Wisdom: Rethinking Persian Modernity in Iran, (Mage 2004); The Persian Sphinx: Amir Abbas Hoveyda and the Riddle of the Iranian Revolution (Mage, 2000); Modernity and Its Foes in Iran (Gardon Press, 1998); Tales of Two Cities: A Persian Memoir (Mage 1996); On Democracy and Socialism, a collection of articles coauthored with Faramarz Tabrizi (Pars Press, 1987); and Malraux and the Tragic Vision (Agah Press, 1982). Milani has also translated numerous books and articles into Persian and English.

Milani received his BA in political science and economics from the University of California at Berkeley in 1970 and his PhD in political science from the University of Hawaii in 1974.

Hamid and Christina Moghadam Director of Iranian Studies
Co-director of the Iran Democracy Project
CDDRL Affiliated Scholar
Date Label
Abbas Milani Panelist Stanford University
Jean-Marie Apostolidès Panelist Stanford University

Shorenstein APARC
Stanford University
Encina Hall E301
Stanford, CA 94305-6055

(650) 723-4560 (650) 723-6530
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Senior Fellow at the Freeman Spogli Institute for International Studies
Denise O'Leary and Kent Thiry Professor
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Andrew G. Walder is the Denise O'Leary and Kent Thiry Professor at Stanford University, where he is also a senior fellow in the Freeman Spogli Institute for International Studies. Previously, he served as Chair of the Department of Sociology, Director of the Walter H. Shorenstein Asia-Pacific Research Center, and Head of the Division of International, Comparative and Area Studies in the School of Humanities and Sciences.

Walder has long specialized in the sources of conflict, stability, and change in communist regimes and their successor states. His publications on Mao-era China have ranged from the social and economic organization of that early period to the popular political mobilization of the late 1960s and the subsequent collapse and rebuilding of the Chinese party-state. His publications on post-Mao China have focused on the evolving pattern of stratification, social mobility, and inequality, with an emphasis on variation in the trajectories of post-state socialist systems. His current research is on the growth and evolution of China’s large modern corporations, both state and private, after the shift away from the Soviet-inspired command economy.

Walder joined the Stanford faculty in 1997. He received his Ph.D. in sociology at the University of Michigan in 1981 and taught at Columbia University before moving to Harvard in 1987. From 1995 to 1997, he headed the Division of Social Sciences at the Hong Kong University of Science and Technology.

Walder has received fellowships and grants from the Guggenheim Foundation, the National Science Foundation, the National Academy of Sciences, the Henry Luce Foundation, the Ford Foundation, the Social Science Research Council, and the Center for Advanced Study in the Behavioral Sciences. His books and articles have won awards from the American Sociological Association, the Association for Asian Studies, and the Social Science History Association. He is an elected member of the American Academy of Arts and Sciences.

His recent and forthcoming books include  Fractured Rebellion: The Beijing Red Guard Movement  (Harvard University Press, 2009);  China Under Mao: A Revolution Derailed  (Harvard University Press, 2015);  Agents of Disorder: Inside China’s Cultural Revolution  (Harvard University Press, 2019); and  A Decade of Upheaval: The Cultural Revolution in Feng County  (Princeton University Press, 2021) (with Dong Guoqiang); and Civil War in Guangxi: The Cultural Revolution on China’s Southern Periphery (Stanford University Press, 2023).  

His recent articles include “After State Socialism: Political Origins of Transitional Recessions.” American Sociological Review  80, 2 (April 2015) (with Andrew Isaacson and Qinglian Lu); “The Dynamics of Collapse in an Authoritarian Regime: China in 1967.”  American Journal of Sociology  122, 4 (January 2017) (with Qinglian Lu); “The Impact of Class Labels on Life Chances in China,”  American Journal of Sociology  124, 4 (January 2019) (with Donald J. Treiman); and “Generating a Violent Insurgency: China’s Factional Warfare of 1967-1968.” American Journal of Sociology 126, 1 (July 2020) (with James Chu).

Director Emeritus, Walter H. Shorenstein Asia-Pacific Research Center
Director Emeritus, Division of International, Comparative and Area Studies
Faculty Affiliate at the Stanford Center on China's Economy and Institutions
Date Label
Andrew G. Walder Commentator Stanford University

Department of History 200-120

(650) 724-0074
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Former Assistant Professor of Modern European History
Former Assistant Professor, by courtesy, of German Studies
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Edith Sheffer joined the History Department faculty in 2010, having come to Stanford as an Andrew W. Mellon Fellow in the Humanities in 2008.  Her first book, Burned Bridge: How East and West Germans Made the Iron Curtain (Oxford University Press, 2011), challenges the moral myth of the Berlin Wall, the Cold War’s central symbol. It reveals how the barrier between East and West did not simply arise overnight from communism in Berlin in 1961, but that a longer, lethal 1,393 kilometer fence had been developing haphazardly between the two Germanys since 1945.

Her current book, Soulless Children of the Reich: Hans Asperger and the Nazi Origins of Autism, investigates Hans Asperger’s creation of the autism diagnosis in Nazi Vienna, examining Nazi psychiatry's emphasis on social spirit and Asperger's involvement in the euthanasia program that murdered disabled children. A related project through Stanford's Spatial History Lab, "Forming Selves: The Creation of Child Psychiatry from Red Vienna to the Third Reich and Abroad," maps the transnational development of child psychiatry as a discipline, tracing linkages among its pioneers in Vienna in the 1930s through their emigration from the Third Reich and establishment of different practices in the 1940s in England and the United States. Sheffer's next book project, Hidden Front: Switzerland and World War Two, tells an in-depth history of a nation whose pivotal role remains unexposed--yet was decisive in the course of the Second World War.

Affiliated faculty at The Europe Center
Edith Sheffer Moderator Stanford University
Lillian Guerra Panelist University of Florida
Silvana Toska Commentator Cornell University
Conferences
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Abstract
The Internet is now approaching near-ubiquity as a method for gathering, distributing and obtaining the news. Over the last decade, social tools and websites built in Silicon Valley have come to dominate that conversation. The use of those tools, the Net and the nature of online journalism varies wildly from country to country. Danny O'Brien of the Committee to Protect Journalists discusses how those tools are used by journalists and their sources in dangerous conditions, and what technologists can learn about the future from these edge cases.

Danny O'Brien is CPJ's Internet Advocacy Coordinator. He has spent over twenty years documenting and explaining the growth of the Internet and new media and its effect on free expression and society. He has written articles for Wired, New Scientist, the Guardian, and TV shows for the BBC. Prior to joining CPJ last year, O'Brien was International activist for the original Internet freedom organization, the Electronic Frontier Foundation, and was a founder of the British pressure group, the Open Rights Group. He is based in San Francisco. http://www.twitter.com/#!/danny_at_cpj

Wallenberg Theater

Danny O'Brien Internet Advocacy Coordinator Speaker Committee to Protect Journalists
Seminars
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Abstract 
There will be a discussion of two different examples of liberation technology, one used to collect and protect human rights data, and the other used to analyze it. Martus is a software program that encrypts and remotely backs up data, designed for and used widely by human rights monitors and advocates to protect witness reports and other sensitive human rights data. the focus will be on the security design of Martus and how we addressed the inevitable tradeoffs with usability, as well as the reasons for and consequences of our choice to make Martus free and open source. The legitimacy of human rights advocates is based on their claim to speak truth about a human rights situation, but our ability to know the truth of what is happening on the ground is often severely limited. Founding conclusions on anecdotes or observable events alone can misinterpret both trends over time and the relative distribution of violence with respect to regions, ethnicity or perpetrators. Through the careful application of rigorous statistical methods, the limitations of incomplete data can sometimes be overcome, enabling scientifically-based claims about the total extent and patterns of human rights violations. Also discussed will be how this kind of analysis is enabled by technology, including computational statistical methods, and tools like R and version control to make the analysis auditable and replicable.

Jeff Klingner is a computer scientist with the Human Rights Data Analysis Group at Benetech, where he codes and runs data analysis addressing a variety of human rights questions, including command responsibility of high-level officials in Chad and Guatemala, and mortality estimation in several countries, including India, Sierra Leone, and Guatemala. His technical focus is on data deduplication, machine learning, data visualization, and analysis auditability and replicability. He earned a Ph.D. in Computer Science from Stanford University.

Wallenberg Theater

Jeff Klingner Computer Science Consultant Speaker Benetech
Seminars
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Abstract
The talk will discuss the impact that recent events in Tunisia, Egypt, Libya, Syria and other MENA countries has had on the debate about the Internet & democracy in general and on the future of the so-called "Internet freedom agenda" in particular. The talk will also explore the possibility of finding some workable middle ground between cyber-utopianism and cyber-dystopianism, attempt to articulate what a more culturally-sensitive approach to studying Internet & democratization may look like and argue for the growing relevance of such approach, particularly as a way to avoid essentialist attitudes towards technology. 
 
Evgeny Morozov is the author of the Net Delusion: The Dark Side of Internet Freedom, published earlier this year and a visiting scholar with the Liberation Technology program at Stanford University. He's also a Schwartz fellow at New America Foundation and a frequent contributor to national and international media on questions of technology and politics. 

Wallenberg Theater

Program on Liberation Technology
616 Serra Street E108
Stanford, California 94305

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Evgeny Morozov is a visiting scholar in the Liberation Technology Program at Stanford University and a Scwhartz fellow at the New America Foundation. He is also a blogger and contributing editor to Foreign Policy Magazine. He is a former Yahoo fellow at the Institute for the Study of Diplomacy at Georgetown University and a former fellow at the Open Society Institute, where he remains on the board of the Information Program. His book The Net Delusion: The Dark Side of Internet Freedom was published by PublicAffairs in January 2011.

Evgeny Morozov Visiting Scholar, Program on Liberation Technology Speaker Stanford University
Seminars
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In this article, Professor Christophe Crombez (Stanford University) and Wim Van Gestel (University of Leuven)  formulate a game-theoretical model of closed rule legislation in the presence of informational asymmetries. In the model, an agenda setter with private information proposes a policy to a legislature. The legislature appoints an oversight committee to monitor the agenda setter. Crombez and Van Gestel study the rationale for this appointment, and analyze the equilibrium oversight committee member choices for the legislators. They conclude that it is optimal for the legislators to appoint oversight committee members who are as far from them as is the agenda setter, but in the opposite direction, rather than do the monitoring themselves. The appointment of such oversight committee members represents a credible means for the legislators to commit to reject proposals that they only marginally prefer to the status quo.
 

 

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Publication Type
Journal Articles
Publication Date
Journal Publisher
The Journal of Theoretical Politics
Authors
Christophe Crombez

Encina Commons Room 180,
615 Crothers Way,
Stanford, CA 94305-6006

(650) 736-0403 (650) 723-1919
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LCY: Tan Lan Lee Professor
Professor, Health Policy
Professor Pediatrics (General Pediatrics)
jason_wang_profile_2019.jpg MD, PhD

C. Jason Wang, M.D., Ph.D. is a Professor of Pediatrics and Health Policy and director of the Center for Policy, Outcomes, and Prevention at Stanford University.  He received his B.S. from MIT, M.D. from Harvard, and Ph.D. in policy analysis from RAND.  After completing his pediatric residency training at UCSF, he worked in Greater China with McKinsey and Company, during which time he performed multiple studies in the Asian healthcare market. In 2000, he was recruited to serve as the project manager for the Taskforce on Reforming Taiwan's National Health Insurance System. His fellowship training in health services research included the Robert Wood Johnson Clinical Scholars Program and the National Research Service Award Fellowship at UCLA. Prior to coming to Stanford in 2011, he was an Assistant Professor of Pediatrics and Public Health (2006-2010) and Associate Professor (2010-2011) at Boston University and Boston Medical Center. 

Among his accomplishments, he was selected as the student speaker for Harvard Medical School Commencement (1996).  He received the Overseas Chinese Outstanding Achievement Medal (1996), the Robert Wood Johnson Physician Faculty Scholars Career Development Award (2007), the CIMIT Young Clinician Research Award for Transformative Innovation in Healthcare Research (2010), and the NIH Director’s New Innovator Award (2011). He was recently named a “Viewpoints” editor and a regular contributor for the Journal of the American Medical Association (JAMA).  He served as an external reviewer for the 2011 IOM Report “Child and Adolescent Health and Health Care Quality: Measuring What Matters” and as a reviewer for AHRQ study sections.

Dr. Wang has written two bestselling Chinese books published in Taiwan and co-authored an English book “Analysis of Healthcare Interventions that Change Patient Trajectories”.  His essay, "Time is Ripe for Increased U.S.-China Cooperation in Health," was selected as the first-place American essay in the 2003 A. Doak Barnett Memorial Essay Contest sponsored by the National Committee on United States-China Relations.

Currently he is the principal investigator on a number of quality improvement and quality assessment projects funded by the Robert Wood Johnson Foundation, the National Institutes of Health (USA), Health Resources and Services Administration (HRSA), and the Andrew T. Huang Medical Education Promotion Fund (Taiwan).

Dr. Wang’s research interests include: 1) developing tools for assessing and improving the quality of healthcare; 2) facilitating the use of innovative consumer technology in improving quality of care and health outcomes; 3) studying competency-based medical education curriculum, and 4) improving health systems performance.

Director, Center for Policy, Outcomes & Prevention (CPOP)
Co-Director, PCHA-UHA Research & Learning Collaborative
Co-Chair, Mobile Health & Other Technologies, Stanford Center for Population Health Sciences
Co-Director, Academic General Pediatrics Fellowship
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A police “encounter killing,” or simply “encounter,” is a term with no legal validity but which has seeped via the media into Indian English so surely that it has acquired a life of its own. It refers to a face-to-face interaction between the police and suspects leading to the killing of the suspects. While intended to convey serendipity, encounter killings in reality are often pre-planned executions by police or security agencies. First used against Maoists in the 1970s, and counterinsurgents in the Northeast and Kashmir, executions as unstated state policy were perfected in dealing with Sikh militant groups in the 80s and 90s. The ‘Punjab solution’, as it came to be known, became the model for the internal security establishment. Mumbai’s underworld was reined in through a series of high profile encounter killings—much celebrated in the popular media for imposing order into the urban anarchy that the gang-wars were breeding. Indeed, this became the preferred quick-fix method of dealing with a range of ‘undesirables’, from petty criminals to gangsters, to alleged terrorists and separatists. But more often than not, those lumped together as ‘encounterables’ were simultaneously marked out through their caste, ethnic and religious affiliations. The talk will discuss the history of fake encounters in India and the role of the media and judiciary in dealing with them.

Manisha Sethi is Assistant Professor at the Centre for the Study of Comparative Religions and Civilizations, Jamia Millia Islamia, New Delhi. Her research interests are in the area of gender and religion, communalism, and law and terrorism. She has published extensively on these themes in academic as well as popular publications. She is currently Associate Editor, Biblio: A Review of Books, India’s premier book review journal, with which she has been associated for over a decade. Sethi is the President of the Jamia Teachers' Solidarity Association, which has been closely involved in a campaign against extra judicial killings. Her book, Escaping the World: Chastity, Power and Women’s Renunciation among Jains, Routledge India, is due later this year.

This event is co-sponsored with the Stanford Center for South Asia and

The Indian American Muslim Council

Philippines Conference Room

Manisha Sethi Assistant Professor, Centre for the Study of Comparative Religions and Civilizations Speaker Jamia Millia Islamia, New Delhi
Seminars
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Russia has had a long history of opposing US missile defense activities. Most recently, Russian concern focused on the alleged capability of the "third site" to intercept Russian ICBMs. The "third site" was a plan to place 10 ground-based interceptors in Poland and a large X-band radar in the Czech Republic proposed by the Bush Administration prior to its cancellation in 2009 by the Obama Administration. Now this same Russian concern has arisen regarding phases III and IV of the Phased Adaptive Approach to European missile defense proposed by the Obama Administration. This talk will assess the extent to which Russian concerns are valid in military/technical terms.


Speaker Biography:

Dean Wilkening is a Senior Research Scientist at the Center for International Security and Cooperation at Stanford University. He holds a Ph.D. in physics from Harvard University and worked at the RAND Corporation prior to coming to Stanford. His major research interests include nuclear strategy and policy, arms control, the proliferation of nuclear and biological weapons, bioterrorism, ballistic missile defense, and energy and security. His most recent research focuses on the broad strategic and political implications of ballistic missile defense deployments in Northeast Asia, South Asia and Europe. Prior work focused on the technical feasibility of boost-phase ballistic missile defense interceptors. His recent work on bioterrorism focuses on understanding the scientific and technical uncertainties associated with predicting the outcome of hypothetical airborne biological attacks and the human effects of inhalation anthrax, with the aim of devising more effective civil defenses. He has participated in, and briefed, several US National Academy of Science committees on biological terrorism and consults for several US national laboratories and government agencies.

Reuben W. Hills Conference Room

Dean Wilkening Senior Research Scientist Speaker CISAC
Seminars
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Antibiotics have represented the primary line of defense for treating bacterial infections since 1935 when the first sulfur-containing compounds were introduced. Many antibiotic compounds are produced naturally by microorganisms while some more recently developed antibiotics are chemically designed based on a knowledge of susceptible biochemical pathways or physiological processes in pathogenic bacteria. Ciprofloxacin (“cipro”), a synthetic broad-spectrum antibiotic, functions by interfering with DNA replication.

Increased use and mis-use of antibiotics has led to increased numbers of pathogenic bacteria that are resistant to one or more antibiotics. Some resistant microbes possess mechanisms that allow continued growth in the presence of multiple antibiotics. These multiply drug-resistant pathogenic bacteria may also possess pathogenic properties that result in significantly more severe disease than their drug-sensitive cousins. Medical misuse of antibiotics – prescribing antibiotics for viral infections, failure of patients to complete treatment with the full regiment of antibiotics, or application of antibiotics based on inaccurate or incomplete tests can lead to selection of antibiotic resistant bacteria that can then cause infections that cannot be treated with the antibiotic(s) to which they are resistant. Multiple drug resistance can quickly reduce or eliminate all antibiotic-based treatment options. Infections caused by antibiotic resistant bacteria are very difficult to treat and can sometimes lead to death of the patient.

Antibiotic resistance can also result from selection based on exposure to antibiotics present in the environment. More than 70% of the antibiotics sold in the U.S. are used as supplements to animal feed. The intestinal bacteria in the animals provided with such feed often show resistance to the antibiotics in the feed and, in some documented cases, have transferred this resistance to pathogenic microbes with which they share the environment.

A brief of history of antibiotic use and the medical and public policy factors that are, in part, responsible for increased antibiotic resistance in pathogenic microbes and for a decrease in the development of new antibiotics will be presented. An introduction to new directions that are being taken to develop a next generation of antibiotic compounds will also be provided.


Speaker Biography:

Paul Jackson received his Bachelor's of Science degree from the University of Washington in Cellular Biology and his Ph.D. from the University of Utah in Molecular Biology. He became a CISAC Visiting Scholar in September 2011. He was previously a CISAC affiliate.

For the past 18 years he has been studying bacterial pathogens, first working to develop DNA-based methods of detecting these microbes and their remnants in environmental and laboratory samples, then developing methods to differentiate among different strains of the same pathogenic species. Research interests include the study of different methods of interrogating biological samples for detection and characterization of content, and development of bioforensic tools that provide detailed information about biothreat isolates including full interrogation of samples for strain content and other genetic traits.

Methods he developed have been applied to forensic analysis of samples and aid in identifying the source of disease outbreaks. He contributed to analysis of the Bacillus anthracis present in the 2001 Amerithrax letters and conducted detailed analyses of human tissue samples preserved from the 1979 Sverdlovsk anthrax outbreak, providing evidence that was inconsistent with Soviet government claims of a natural anthrax outbreak.

His current work continues to focus on development of assays that rapidly detect specific signatures including antibiotic resistance in threat agents and other pathogens. More recent activities include identification and characterization of new antimicrobial compounds that are based on the pathogens' own genes and the products they encode. These include development of such materials as therapeutic antimicrobials, their application to remediate high value contaminated sites and materials, and their use to destroy large cultures and preparations of different bacterial threat agents. Efforts to address issues of antibiotic resistance and treatment of resistant organisms have recently been expanded to look at non-threat agent pathogens that cause problematic nosocomial or community-acquired infections of particular interest to the military.

Paul spent 24 years as a Technical Staff Member at Los Alamos National Laboratory where he was heavily involved in development of the biological threat reduction efforts there. He was appointed a Laboratory Fellow at Los Alamos in recognition of his efforts. He moved to Lawrence Livermore National Laboratory in 2005 where he is presently Senior Scientist in the Global Security and Physical and Life Sciences Directorates. In addition to his work at the National Laboratories, he has served on the FBI's Scientific Working Group for Microbial Forensics, on NIH study sections and review panels, and continues to serve on steering and oversight committees for other federal agencies.

Reuben W. Hills Conference Room

Paul J. Jackson Visiting Scholar Speaker CISAC
Seminars
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Much study has been put into the concept of a multinational or international “nuclear fuel bank,” and in 2010 two such banks became a reality according to the Nuclear Threat Initiative. However, all of the conceptual studies along with the two IAEA-approved banks are not really “fuel” banks; rather they are low-enriched uranium (LEU) reserves. While uranium is a commodity, fuel for a nuclear reactor is a highly-engineered product of which uranium is a component.

It has been argued that because there are more fuel fabricators than enrichers, the enrichment step is the crux of a supply assurance mechanism. This is a gross oversimplification. If one cannot get from LEU to a fabricated fuel assembly, then the fuel supply assurance is not available. There are issues of fuel design, core physics, regulation, intellectual property, and liabilities that could preclude fuel fabrication and delivery in a timely manner. These issues and obstacles will be discussed along with some suggestions about how they might be overcome to provide real fuel assurances.


Speaker Biography:

Dr. Alan Hanson was appointed as Executive Vice President, Technologies and Used Fuel Management of AREVA NC Inc. in 2005. In this position he was responsible for all of AREVA’s activities in the backend of the nuclear fuel cycle in the U.S. Prior to that he served as President and CEO of Transnuclear, Inc., also an AREVA company, which he joined in 1985. Transnuclear designs, licenses and supplies dry storage casks; more than half of the casks in the U.S. have been supplied by Transnuclear.

In January of 2011, Dr. Hanson started a year-long assignment as a Visiting Scholar at the Center for International Security and Cooperation (CISAC) at Stanford University on loan from AREVA. At CISAC he conducts research on the worldwide nuclear supply chain and international fuel assurance mechanisms. 

Dr. Hanson began his career in 1975 with the Nuclear Services Division of Yankee Atomic Electric Company. In 1979, he joined the International Atomic Energy Agency (IAEA) in Vienna, Austria. At the IAEA, he served first as Coordinator of the International Spent Fuel Management Program and later as Policy Analyst with responsibilities in the areas of safeguards and non-proliferation policies.

Alan Hanson received a B.S. degree in mechanical engineering from Stanford University in 1969 and earned his Ph.D. in nuclear engineering from Massachusetts Institute of Technology (MIT) in 1977. He also is a recipient of a Master of Arts in Liberal Studies (MALS) degree from Georgetown University in 2009.  He is a member of the American Nuclear Society and the American Society of Mechanical Engineers.

CISAC Conference Room

Alan Hanson Visiting Scholar Speaker CISAC
Seminars
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