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Background

The pandemic of antimicrobial resistance (AMR) will only be mitigated by policy action and innovation and importantly, supported by local and community action. With the United Nations General Assembly high level meeting on AMR taking place in September 2024, we decided to ascertain citizens’ understanding of the issues and prioritisation for action.

Methods

From June to August 2024, while intergovernmental negotiations on the outcome document were taking place, we used Deliberative Polling®, a methodology founded on deliberative democratic theory, in six middle income countries across three continents to explore people’s understanding and support for 45 policies that were likely to feature in the political declaration.

Results

In total 2419 participants were randomised to deliberation intervention (written and video information, facilitated online small group discussions, and expert plenary sessions) or control groups who only completed the pre- and post-deliberation surveys. Support increased significantly through deliberation for 3/4 of the proposals (>90% for 2/3), as well as on knowledge about AMR and internal political efficacy. Proposals relating to infection prevention were most heavily supported across all six countries. We found regional variation in support for proposals relating to informal antibiotic access and the use of antibiotics in food production, with less support for selected proposals from South America.

Conclusions

Deliberative polling is a powerful method of large scale community engagement and this is new for AMR helping us to understand the views of the public relating to policies that will require their support to enact.

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[version 2; peer review: 2 approved, 3 approved with reservations]

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Wellcome Open Res 2026
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Alice Siu
James S. Fishkin
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10:690
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For the second time in history, UN Member States adopted a Political Declaration on AMR in 2024. This declaration outlines ambitious commitments to tackle one of the most pressing health challenges of our time. These commitments will only be successful if the public understands, supports, and ultimately changes behavior to make them work.

Ahead of UNGA, we asked citizens in six countries what they thought about different policy proposals across six themes: Equity, Access and Stewardship; Infection Prevention; Food Security; Awareness and Education; Target setting; and Surveillance.

Working with the Trinity Challenge, we brought together 2,419 citizens from Brazil, Colombia, Nigeria, Tanzania, India, and Indonesia using Deliberative Polling®, a method that assesses what a representative and informed sample would think about policy proposals after extended, evidence-based discussions. Deliberations took place on the innovative Artificial Intelligence (AI)-assisted Stanford University Online Deliberation Platform across two days.

Citizens left the process not just more informed, but more engaged with the solutions required.

What is Deliberative Polling® ?


Deliberative Polling® is a research methodology developed by Professor James Fishkin at Stanford University's Deliberative Democracy Lab. Unlike standard opinion polling, it measures not just initial public opinion but informed public opinion - what people think after genuine engagement with the issues, trade-offs, and expert perspectives.

It has been applied in over 160 cases around the world, from national referendums to climate policy.

Learn more about the Deliberative Polling® methodology.

"Deliberative Polling® doesn't just ask what people think - it asks what they would think if they had the chance to really engage with the evidence."
Professor James Fishkin
Stanford Deliberative Democracy Lab

Key Findings


The results were striking - and they matter for policymakers, health leaders, and the public alike.

🌍 2,419 citizens across six middle-income countries participated
📈 43 out of 45 policy proposals saw increased support after deliberation
✅ The most popular proposals were those relating to infection prevention
🌐 Regional differences emerged — particularly around attitudes to restricting antibiotic use in food production.

Antimicrobial resistance is not only a scientific challenge but a societal one. This project shows that when citizens are given balanced information, diverse perspectives, and the opportunity to deliberate, they can engage meaningfully with the complexity of AMR and support the action it requires. Building public trust and community engagement is essential to reducing the global impact of AMR. We hope these findings and resources will help advance public engagement on AMR and strengthen deliberative approaches across global health.

Support increased for 43 out of 45 proposals following deliberation. Beyond the data, participants left better informed about AMR and more engaged with the solutions on the table. That is whole-of-society action in practice.
Dame Sally Davies
Master of Trinity College Cambridge and Executive Chair of the Trinity Challenge

From Understanding to Action


This study demonstrates something important: when citizens are given the chance to engage seriously with a complex global health challenge, they rise to it.

Across all six countries, deliberation moved public opinion towards greater support for ambitious AMR action — on prescription practices, agricultural use, access to medicines, and prevention. The 2024 UN Political Declaration set out what governments have committed to. This research shows that the public, when informed, is ready to support it.

The findings have direct relevance for:

  • Policymakers designing national AMR action plans, particularly in middle-income countries
  • Health communicators seeking evidence-based approaches to public engagement on AMR
  • Researchers building the evidence base for deliberative approaches in global health
  • Civil society organizations advocating for community-level AMR action
     

We are committed to sharing these findings as widely as possible — with governments, health bodies, and the communities that took part.

Thanks to our funders


With thanks to the Novo Nordisk Foundation and Wellcome.

Contact and Media


For media inquiries and further information about the research, please contact Louise Gough (Chief Operating Officer) at info@thetrinitychallenge.org.

Read our press release.

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The Deliberative Democracy Lab and the Trinity Challenge asked 2419 people in six countries through the first-ever deliberative poll on AMR.

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Panel Discussion followed by Keynote with Dr. Chelsea Clinton & Secretary Condoleezza Rice

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Researchers analyzed three decades of sanctions on foreign aid to assess their impact on health. They hope the work can help government officials better understand and address how foreign policy decisions affect the well-being of local populations.

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COVID-19 temperature testing in China.

The COVID-19 crisis was a profound stress test for health, economic, and governance systems worldwide, and its lessons remain urgent. The pandemic revealed that unpreparedness carries cascading consequences, including the collapse of health services, the reversal of development gains, and the destabilization of economies. The magnitude of global losses, measured in trillions of dollars and millions of lives, demonstrated that preparedness is not a discretionary expense but a foundation of macroeconomic stability. Countries that invested early in surveillance, resilient systems, and inclusive access managed to contain shocks and recover faster, proving that health security and economic security are inseparable.

For the Asia-Pacific, the path forward lies in transforming vulnerability into long-term resilience. Building pandemic readiness requires embedding preparedness within fiscal and development planning, not as an emergency measure but as a permanent policy function. The region’s diverse economies can draw on collective strengths in manufacturing capacity, technological innovation, and strong regional cooperation to institutionalize the four pillars— globally networked surveillance and research, a resilient national system, an equitable supply of medical countermeasures and tools, and global governance and financing—thereby maximizing pandemic prevention, preparedness, and response. Achieving this will depend on sustained political will and predictable financing, supported by the catalytic role of multilateral development banks and international financial institutions that can align public investment with global standards and private capital.

The coming decade presents a narrow but decisive window to consolidate these gains. Climate change, urbanization, and ecological disruption are intensifying the probability of new zoonotic spillovers. Meeting this challenge demands a shift from episodic response to continuous readiness, from isolated health interventions to integrated systems that link health, the environment, and the economy. Strengthening regional solidarity, transparency, and mutual accountability will be vital in ensuring that no country is left exposed when the next threat emerges.

A pandemic-ready Asia-Pacific is not an aspiration but an imperative. The lessons of COVID-19 call for institutionalized preparedness that transcends political cycles and emergency budgets. By treating health resilience as a global public good, the region can turn its experience of crisis into a model of sustained, inclusive security for the world.

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Building a Pandemic-Ready Asia-Pacific

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Lecturer, Medicine - Primary Care and Population Health
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Gordon founded the Social Entrepreneurship Collaboratory (SE Labs) at Stanford, Harvard and Princeton. He teaches about the design, development and leadership of innovative social impact ventures in global health and environmental sustainability.

At Stanford, Gordon is director of the Social Entrepreneurship and Innovation Lab (SE Lab)- Human & Planetary Health and is a faculty fellow of the Center for Innovation in Global Health. He is a Lecturer in the School of Medicine, Division of Primary Care and Population Health/Dept. of Medicine, and an advisor in the Distinguished Careers Institute (DCI), and the Knight-Hennessy Scholars Program, and cofounder of the Stanford Sustainable Societies Lab.

At Harvard, Gordon taught jointly on the faculties of the Harvard T. H. Chan School of Public Health (Health Policy & Management) and the Harvard Kennedy School (Management, Leadership & Decision Sciences) and served as an Expert-in-Residence (EiR) at the Harvard Innovation Lab (i-Lab), and affiliated faculty at the Center for Primary Care, Harvard Medical School (HMS). He was faculty director of the Social Entrepreneurship and Innovation Lab (SE Lab) for US & Global Health, an incubator course taught in a new interdisciplinary, collaborative model based at the i-Lab. He has also served as an Entrepreneur-in-Residence (2013-2014) at Harvard Business School in the Rock Center for Entrepreneurship, on the Faculty of Arts & Sciences in the Sociology Department, at the Harvard Kennedy School, on the Leadership & Management faculty, and as a principal of the Hauser Center for Non-Profit Organizations (2004-2007). Gordon served as one of the founding faculty of the $10 million Reynolds Fellows Program in Social Entrepreneurship, a Center for Public Leadership and Harvard President’s interdisciplinary fellowship initiative that paid full tuition and stipend for graduate students from the Harvard Kennedy School, School of Public Health and Graduate School of Education.

At Princeton, Gordon served as Dean’s Visiting Professor in Entrepreneurship in 2009-2010. Working together with the School of Engineering & Applied Science, the [Woodrow Wilson] School of Public & International Affairs, and the Faculty of Arts & Sciences, he launched a new set of programs and prizes in social innovation and entrepreneurship in collaboration with students, faculty and alumni.

At Stanford in 2001-2002, Gordon created the SE Lab, a Silicon Valley and technology–influenced, interdisciplinary incubator for social impact ventures and global problem solving. Gordon taught on the Public Policy Program and Urban Studies Program faculties (School of Humanities & Sciences) and served as a faculty affiliate at the Center for Social Innovation at Stanford Graduate School of Business, and a Program Officer at Stanford’s Freeman Spogli Institute for International Studies.

Many of the talented students and fellows in Gordon’s SE Labs have won the top awards of prestigious idea and business plan competitions, including those at Stanford, Harvard, Princeton and MIT.

Gordon is a co-author in the edited volume Frontiers in Social Innovation (N. Malhotra, ed., Harvard Business Review Press, 2022) and Social Entrepreneurship: New Models of Sustainable Social Change (A. Nicholls, ed., Oxford University Press, 2006/2008) and served as a founding member of the Oxford/Ashoka led University Network for Social Entrepreneurship. His interest in entrepreneurship is informed by work in both the private and nonprofit sectors in the U.S. (New York, Cambridge, Palo Alto), Europe (London, Paris) and Asia (Hong Kong), as CEO of a medical technology company (EDAP Technomed, USA) and in international strategy consulting (Bain & Co. Ltd.).

Gordon is married to Sara Singer- they on occasion teach together at Stanford, have a daughter Audrey and son Jason, and live in the Frenchman's Hill residential section of campus.

Co-founder, Stanford Sustainable Societies Lab
Director, Stanford Social Entrepreneurship and Innovation Lab (SE Lab)- Human & Planetary Health
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Argument and Contribution


At the national level, the United States struggled to effectively respond to the COVID-19 pandemic: federal policy was delayed and inconsistent, supply shortages were widespread, and political pressure undermined accurate public health guidance. At the state and local levels, however, there was a great deal of variation in terms of the capacity to respond to COVID. While indicators of state capacity often focus on “formal” indicators like institutional resources, staffing, and finances, translating formal capacities into effectively implemented policies is neither a simple nor an automatic process. 

In “Building the Plane While Flying,” Didi Kuo and Andrew S. Kelly draw our attention to the importance of informal indicators of public health capacity. These include strong relationships within and across government agencies, the embeddedness of health officers in local communities, and prior experience with responding to disasters, among other factors. The authors argue that local governments with strong informal capacity were better able to communicate with and learn from one another, as well as to gain the trust of community members, during the pandemic. Conversely, localities with otherwise strong formal capacities often failed to respond to the challenges at hand. This is because they were unable to effectively leverage their relationships and organizational networks.
 


The authors argue that local governments with strong informal capacity were better able to communicate with and learn from one another, as well as to gain the trust of community members, during the pandemic.


Kuo and Kelly’s paper is informed by qualitative analysis of California’s public health institutions as well as in-depth interviews with health officers across seventeen Northern, Central, and Southern California counties. The interviews illuminate the concrete processes by which local governments responded (or struggled to respond) to the COVID-19 pandemic. One of the paper’s key contributions is to push us to conceptualize state capacity more broadly and to focus on the factors that drive not just policy development, but policy implementation. 

The Importance of Informal Capacity


The bulk of the paper disaggregates informal capacity into its various mechanisms and processes. Each of these proves to be crucial in explaining different pandemic outcomes at the local level. One such mechanism is coordination within local governments. To illustrate this, consider public health officers, who enjoy broad legal powers to protect public health as well as financial resources and personnel at their disposal. By law, officers possess significant capacities to mitigate health crises. Yet across the interviews, health officers reported that effectively implementing COVID-19 policy required their cooperation and communication with a host of actors, including the County Counsel (the county’s top lawyer), Chief Administrative Officer, and Board of Supervisors, which is charged with appointing health officers.
 


Closely related to intra-governmental coordination is the importance of autonomy, particularly in the face of political pressure.


Closely related to intra-governmental coordination is the importance of autonomy, particularly in the face of political pressure. For example, boards of supervisors sometimes undermined the public guidance provided by health officers. (This guidance could range from the need to close schools to officers simply communicating truthfully with localities about COVID-19 risks.) Overcoming efforts by board members to ignore or muzzle officers required coordination between those actors who were more insulated from political pressure.

Another key component of informal capacity was prior experience responding to emergencies and California’s myriad of natural disasters, such as fires, floods, or mudslides. Health officers from more experienced counties noted their ability to draw upon established emergency procedures and partnerships. For example, some counties had previously cooperated with each other, as well as with independent agencies like the Red Cross, to provide aid and shelter to those affected by wildfires. These experiences — for which no amount of financial resources or personnel can substitute — served as templates to help coordinate COVID-19 policy responses.

Informal capacity also depended upon health departments effectively communicating with the public. Many departments initially lacked the infrastructure to do this, and therefore relied on cooperation with other actors like school superintendents, sheriffs, and community leaders. Some counties created toolkits to improve their community’s understanding of personal protective equipment (PPE) or even produced local TV shows. Still others scheduled conference calls with local hospitals, faith leaders, and nursing homes. Given that many of these communication efforts were improvised, public health officers stressed the importance of formalizing coordination between state and nonstate actors so as to improve emergency preparedness in the future.
 


In addition to coordination within local governments, effective policy-making and communication required coordination across governments.


In addition to coordination within local governments, effective policy-making and communication required coordination across governments. One such institution was the Association of Bay Area Health Officers (ABAHO), founded in the 1980s during the HIV/AIDS epidemic. ABAHO members had also coordinated policy responses to the H1N1 outbreak. These cross-county partnerships enabled early, rapid, and unified responses to the COVID-19 pandemic. By contrast, the authors find that regions without such networks faced greater challenges in developing and implementing public policy.

A final aspect of informal capacity is the social embeddedness of health officials in their communities. This includes partnerships with leaders of businesses and faith groups, teachers, and restaurant owners. Not only did these partnerships increase the scope of outreach, but they also often established relationships that had not existed beforehand. Gaining a foothold in local communities thus increased the likelihood that community members would support policies and enabled local governments to access hard-to-reach populations.
 


For federal, decentralized countries like the US, informal capacities and relationships are essential not only for delivering services but for generating legitimacy and trust among those receiving services.


Kuo and Kelly’s analysis of informal capacity should give us pause when considering existing indices of public health preparedness; some of these have ranked the United States quite high despite its often ineffective responses to the COVID-19 pandemic. That this mismatch occurs is arguably a function of observers prioritizing formal capacities. For federal, decentralized countries like the US, informal capacities and relationships are essential not only for delivering services but for generating legitimacy and trust among those receiving services.

*Research-in-Brief prepared by Adam Fefer.

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Public health infrastructure varies widely at the local, state, and national levels, and the COVID-19 response revealed just how critical local health authority can be. Public health officials created COVID policies, enforced behavioral and non-pharmaceutical interventions, and communicated with the public. This article explores the determinants of public health capacity, distinguishing between formal institutional capacity (i.e., budget, staff) and informal embedded capacity (i.e., community ties, insulation from political pressures). Using qualitative data and interviews with county health officers in California, this article shows that informal embedded capacity—while difficult to measure—is essential to public health capacity. It concludes by relating public health capacity to broader issues of state capacity and democracy.

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Shorenstein APARC's annual report for the academic year 2023-24 is now available.

Learn about the research, publications, and events produced by the Center and its programs over the last academic year. Read the feature sections, which look at the historic meeting at Stanford between the leaders of Korea and Japan and the launch of the Center's new Taiwan Program; learn about the research our faculty and postdoctoral fellows engaged in, including a study on China's integration of urban-rural health insurance and the policy work done by the Stanford Next Asia Policy Lab (SNAPL); and catch up on the Center's policy work, education initiatives, publications, and policy outreach. Download your copy or read it online below.

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Hanwen Zhang is an academic editor at the Stanford Center on China’s Economy and Institutions. He grew up in Shanghai, China and graduated in 2024 with a B.A. in Sociology and Psychology from Middlebury College, where he studied public beliefs and decision-making about inequality. While at SCCEI, Hanwen will be working with the Rural Education Action Program and hopes to use his cross-cultural background to build a community for scholars.

Academic Editor, Rural Education Action Program
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