Health and Medicine

FSI’s researchers assess health and medicine through the lenses of economics, nutrition and politics. They’re studying and influencing public health policies of local and national governments and the roles that corporations and nongovernmental organizations play in providing health care around the world. Scholars look at how governance affects citizens’ health, how children’s health care access affects the aging process and how to improve children’s health in Guatemala and rural China. They want to know what it will take for people to cook more safely and breathe more easily in developing countries.

FSI professors investigate how lifestyles affect health. What good does gardening do for older Americans? What are the benefits of eating organic food or growing genetically modified rice in China? They study cost-effectiveness by examining programs like those aimed at preventing the spread of tuberculosis in Russian prisons. Policies that impact obesity and undernutrition are examined; as are the public health implications of limiting salt in processed foods and the role of smoking among men who work in Chinese factories. FSI health research looks at sweeping domestic policies like the Affordable Care Act and the role of foreign aid in affecting the price of HIV drugs in Africa.

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Beth Duff-Brown
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Renowned economist Jeffrey Sachs launched an ambitious — some would say audacious — experiment back in 2005 in his quest to prove that we can end global poverty if we take a holistic, community-led approach to sustainable development.

The Millennium Villages Project targeted more than a dozen sub-Saharan villages and imposed an integrated approach to help these villages achieve the U.N. Millennium Development Goals to address poverty, health, gender equality, and disease.

Funded by World Bank loans, governments, and private contributions, the pilot wanted to see whether conditions would improve dramatically for the half-million residents of the villages in the 10 project sites by improving access to safe drinking water, primary education, basic health care, and other science-based interventions such as better seeds and fertilizer.

The results are in. And boy are they are mixed.

Some harsh critics say the MVP was a waste of hundreds of millions of dollars, the project was riddled with fundamental methodological errors, and there is little scientific evidence that the project attained its goals.

Others, such as Sachs himself in this Lancet Global Health perspective, say that while the outcomes on poverty were mixed and impacts on nutrition and education often inconclusive, “the lessons learned from the MVP are highly pertinent.”

Stanford Health Policy’s Eran Bendavid — asked to contribute a commentary about the endline evaluation of the project published online this month in The Lancet Global Health — falls somewhere between critic and advocate.

"The project, set up as a focused set of interventions implementing an important idea in international development about how to best help the poor, was a terrific opportunity for learning about how to reduce poverty and improve well-being,” Bendavid said.

But the MVP was not set up as a randomized field trial, nor was there any monitoring of what happened in any comparison areas to make sense of what the intervention had achieved.

“No comparison sites were selected either. That was a wasted opportunity,” he said. “The endline evaluation of the project does the best that can be done to eek some information from the limited opportunities for learning.”

Bendavid, an associate professor of medicine and an infectious diseases physician who focuses on global health, said the project invested about $120 per person per year for 50,000 people for 10 years. That’s about $600 million.

“The clearest evidence of benefits from this investment is improved maternal health-care and health outcomes,” he said.

The authors of the final evaluation tried to put a better spin on the net benefits.

 

 

“We found that impact estimates for 30 of 40 outcomes were significant and favored the project villages,” wrote the authors of The Millennium Villages Project: a retrospective, observational, endline evaluation.

“In particular, substantial effects were seen in agriculture and health, in which some of the outcomes were roughly one (standard deviation) better in the project villages than in the comparison villages,” they wrote. However, they added, “The project was estimated to have no significant impact on the consumption-based measures of poverty,” and impacts on nutrition and education outcomes were often inconclusive.

But when they averaged outcomes within categories, the authors — of whom Sachs was one — concluded that the project had significant favorable impacts on agriculture, nutrition, education, child health, maternal health, HIV and malaria, and water and sanitation.

In all, a third of the targets of the Millennium Development Goals were met in the project sites.

Bendavid concluded that the endline evaluation “marks an important chapter in our understanding of Africa’s meandering path towards health and economic development.” 

He noted that the project’s evaluation, which was done as well as possible given the difficulties of assessing its impact 10 years on, still failed to shed much light on the MVP’s approach as a method to bring an end to poverty. 

“This was such an important project,” Bendavid said. “We’ll never fully know where it succeeded and where it did not, but this evaluation is a welcome bookend to what we are likely to ever learn from that experience.”

Listen to a podcast with Bendavid.

 

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Jeffrey Sachs, special advisor to UN Secretary General on the Millennium Development Goals, delivers a speech at a UN Economic and Social Council meeting in New York City. Sachs is attempting to implement a plan to meet the Millennium Development Goals which would lift hundreds of millions out of poverty and save tens of millions of lives.
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The major objectives of this paper are: 1) to investigate how local nutritional availability in early childhood and in adolescence affected health and human capital development; 2) to explore if improved nutrition in adolescence could mitigate the negative effects of early-life exposure to negative health shocks generated by the Korean War; and 3) to understand how increased nutritional supply contributed to the improvement in health in South Korea from 1946 to 1977.

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Chulhee Lee is professor of economics at Seoul National University. After receiving his doctoral degree from University of Chicago in 1996, he taught at SUNY Binghamton before he returned to Seoul in 1998. His major research topics are economic status and labor-market behaviors of older persons; and interactions of ecological environment, socioeconomic status, and health over the life course. Lee has been involved with the management of the NIH-funded Early Indicators project since 2001 as project leader and senior investigator, which constructed and analyzed longitudinal data on Union Army soldiers. He has also participated in various projects of creating and studying new data in Korea, such as the Korea Longitudinal Study of Aging (KLOSA), the panel data on the Korean Health Insurance, and the sample of military records in Korea. Lee’s research on the health and retirement of US Civil War soldiers has been published in American Economic Review (1998), Journal of Economic History (1998, 2002, 2005, 2008), Explorations in Economic History (1997, 1998, 2007, 2012), and Social Science History (1999, 2005, 2009, 2015). He has also published paper on retirement of Koreans in Economic Development and Cultural Change (2007) and Journal of Population Ageing (2013). His recent work on the effects of in-utero exposure to the Korean War, recessions, and the 1980 Kwangju uprising appeared in Journal of Health Economics (2014), Social Science and Medicine (2014), Health Economics (2017), and Asian Population Studies (2017).

Chulhee Lee Department of Economics, Seoul National University
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Changes in Clinical Practice Among Physicians with Legal Problems

David Studdert, LLB, ScD, MPH with Co-Authors Michelle Mello, PhD, JD & Matthew Spittal, PhD

Recent evidence indicates that a small group of physicians accounts for a surprisingly large share of all malpractice claims and patient complaints.  Next to nothing is known about the career trajectories of these claim-prone physicians.  Do they continue to practice, and if so, do they alter their clinical load?  Do they cut ties—voluntarily or involuntarily—with hospitals and large practice groups?  Do they seek to put their checkered history behind them by relocating—interstate or to areas where clinicians are in short supply?  We explore these questions in a large cohort of US physicians. 

RSVP is now closed.

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The Effect on Healthcare Costs of Treating Comorbid Depressive Disorder with Chronic Disease

Objective: Does the cost of treating depressive disorder comorbidity inflate the cost of treating other chronic conditions?  The answer is important both to payers and to those organizing health care delivery.

Methods: Results from the national Medical Expenditure Panel Survey of 2015 (N≈30,000) provided the data. We estimated costs from medical records and from the self-reported utilization of healthcare. Using the Mental Health Component Summary score of the 12-Item Short Form we estimated the level of depression. We used a general linear model to estimate costs with fixed effects for chronic disease (present or absent) and depression (highest third, middle third, lowest third). Physical health/functional status served as a covariate. We analyzed each of eight different chronic conditions (arthritis, chronic obstructive pulmonary disease, high cholesterol, cancer, diabetes, stroke, coronary heart disease, and asthma) separately.

Results: In each of these analyses, the presence or absence of the chronic condition had a strong impact on cost. In addition, being at the highest level of depression also had a significant impact on cost. However, the interaction between depression and chronic disease diagnoses tended to account for only a small amount of variation in cost.

Conclusion: The combination of depression and chronic disease diagnosis did not have a strong synergistic effect on the cost of medical care. An additive model provides a more parsimonious explanation of data from this national sample.


Robert M. Kaplan, PhD

Clinical Excellence Research Center, Stanford University School of Medicine

Robert M. Kaplan, PhD is research director at CERC.  He has served as Chief Science Officer at the US Agency for Health Care Research and Quality (AHRQ) and Associate Director of the National Institutes of Health, where he led the behavioral and social sciences programs.  He is also a Distinguished Emeritus Professor of Health Services and Medicine at UCLA, where he led the UCLA/RAND AHRQ health services training program and the UCLA/RAND CDC Prevention Research Center. He was Chair of the Department of Health Services from 2004 to 2009.  From 1997 to 2004 he was Professor and Chair of the Department of Family and Preventive Medicine, at the University of California, San Diego. He is a past President of several organizations, including the American Psychological Association Division of Health Psychology, Section J of the American Association for the Advancement of Science (Pacific), the International Society for Quality of Life Research, the Society for Behavioral Medicine, and the Academy of Behavioral Medicine Research. Kaplan is a former Editor-in-Chief of Health Psychology and of the Annals of Behavioral Medicine.  His 20 books and over 500 articles or chapters have been cited more than 30,000 times and the ISI includes him in the listing of the most cited authors in his field (defined as above the 99.5th percentile).  Kaplan is an elected member of the National Academy of Medicine (formerly the Institute of Medicine).  Dr. Kaplan is currently Regenstrief Distinguished Fellow at Purdue University and Adjunct Professor of Medicine at Stanford University.


Lunch will be provided to those who RSVP.

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Moving Precision Medicine into Clinical Care and Health Policies: UCSF, Stanford, and Beyond

Precision medicine has evolved from a distant promise to reality, with many genomic tests now used in clinical care. Dr. Phillips will discuss the opportunities for researchers and clinicians to address the health policy implications of precision medicine, with a particular focus on opportunities at UCSF and Stanford. She will discuss a case study of a recent and highly controversial CMS national coverage decision on sequencing tests for cancer patients based on her article in JAMA 4/16/2018 (Phillips KA. Evolving Payer Coverage Policies on Genomic Sequencing Tests: Beginning of the End or End of the Beginning?)


Kathryn A. Phillips, PhD

Professor of Health Economics and Health Services Research and Founding Director, UCSF Center for Translational and Policy Research on Personalized Medicine University of California, San Francisco

Kathryn Phillips’s expertise is in the implementation of new technologies to improve healthcare. In 2007, she founded the UCSF Center for Translational and Policy Research on Personalized Medicine, which focuses on how to develop objective evidence on value and payer coverage of precision/personalized medicine. Dr. Phillips has published ~150 articles in major journals, including JAMA, New England Journal of Medicine, and Health Affairs, and has had continuous funding from the NIH as a Principal Investigator for 25 years. She serves on the editorial boards of the journals Health Affairs and Value in Health as well as all of the leading journals on precision medicine. A distinguishing characteristic of Dr. Phillips’ work is the translation of science into policy by bringing together perspectives across stakeholders. She has worked extensively with health plans, industry, and government agencies across the globe and has served on national and international scientific advisory committees for the National Academy of Medicine, Food and Drug Administration, and the President’s Council of Advisors on Science and Technology. Dr. Phillips is now serving on the Board of Directors for GenomeCanada (a non-profit organization that oversees and funds genomic research in Canada). In 2016, she was awarded a Rockefeller Foundation Bellagio Residency to pursue her work from a global perspective. Dr. Phillips holds degrees from UC-Berkeley, Harvard, and UT-Austin.


Lunch will be provided to those who RSVP.

Oksenberg Conference Room

Encina Hall

616 Serra Street

Stanford, CA 94305

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As millions marched against gun violence across the country on Saturday, research by Stanford Health Policy experts about the impact of gun ownership on public health was also in the spotlight.

The Washington Post published an in-depth story about how the work of gun researchers is finally getting attention — an unfortunate consequence of the recent mass shootings in the United States.

David Studdert — a professor of medicine and law — and Yifan Zhang, a biostatics and data analyst with Stanford Health Policy, along with seasoned gun researcher Garen Wintemute of UC Davis’s Violence Prevention Research Program, are trying to answer the question: Are you more or less likely to die if you own a firearm?

“The explosion of national interest in the problem of gun violence since the Parkland shooting has been remarkable,” said Studdert, who is also a core faculty member at Stanford Health Policy.  “And it is inspiring to hear students’ voices — that is definitely a new twist in the politics around this issue. I think there is momentum for change, but I remain pessimistic that we will see the enactment of any substantial reforms at the federal level.”

The Post wrote:

Studdert’s group is using a data set unique to California because of the state’s strict gun laws. Every time a gun is sold in California, a background check logs the purchase and purchaser with California authorities, who also have been unique in their willingness to share such politically fraught data with academic researchers.

 

Using a sample of 25 million people (taken from California’s voter registration records), Studdert’s team plans to identify handgun owners with the firearm sales records, then compare that against state death records.

 

The resulting data in theory will help them determine the relationship — whether good or bad — between gun ownership and death.

 

They call the project LongSHOT, a nod to the project’s scale and ambition.

 

Academic researchers who were studying the impact of gun violence on public health were dealt a huge financial and political blow in 1996, when the so-called Dickey Amendment was passed by Congress under pressure from gun lobbyists. The law forbids the Centers for Disease Control and Prevention to fund research that might be seen as advocating for gun control. This choked off federal grant money and essential data-gathering on gun violence.

But tucked into the government spending bill in Congress last week was language that indicates the CDC now has the authority to conduct research on the causes and effects of gun violence. Though gun researchers are skeptical that the change in tone will lead to any significant support or funding, some believe that it’s a start. The $1.3 trillion government funding measure also includes efforts to improve state compliance with the national background check system, as well as funding for school counseling and safety programs.

Again, from The Post story:

Yifan Zhang was finishing her PhD in biostatistics at Harvard five years ago when news broke of the Sandy Hook Elementary School shooting.

 

As a graduate student from China, specializing in highly technical design of clinical drug trials, she had little connection to America’s long-running debate over gun violence. But even now, she said, the anguished faces of those parents she saw on television remain seared in her memory.

 

So when she heard about a gun-violence research project at Stanford University that could use the statistical skills she had honed on pharmaceuticals, she jumped at the chance.

 

“I have a son who just turned 1,” said Zhang, 31. “When I think about what I will need to teach him about protecting himself, I think about that school shooting.”

 

Zhang hopes the Stanford team can one day have an impact.

“I think there are going to be some big decisions that the whole country has to make together, and I’m hoping that our research can help provide evidence and information for the decision making,” she said.

 

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Health care has become the largest sector of the global economy, now accounting for more than 10 percent of Gross World Product, or $7.5 trillion. And it’s only going to get bigger as economists expect that figure to approach $18 trillion in two decades.

And yet, the quality of care and health outcomes are not keeping pace.

Ashish K. Jha — a leading expert on health policy and director of the Harvard Global Health Institute — calls this a “critical moment” in health care as the standard of care increasingly becomes more important than the number of people who have health coverage around the world.

“The point is, coverage is not coverage is not coverage. All health financing schemes are not the same,” said Jha, noting that China and Canada have universal coverage for its citizens, but many still receive inadequate health care or are going broke due to the high cost of special medical needs.

“In many places, the problem is the shallowness of the coverage.  Everyone may be covered — but if you get really sick, shallow coverage gets people into trouble,” said Jha, a keynote speaker at the annual Global Health Economics Colloquium, which brings together health economists and policy experts from University of California San Francisco, UC Berkeley and Stanford Health Policy to discuss recent developments in their fields.

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The fifth colloquium identified the health needs of vulnerable populations and developing cost-effective and scalable interventions to improve the health of socially and economically disadvantaged people here in the United States and in low- and middle-income countries.

“Our hope for the day is that our speakers will remind us why we do what we do, remind us why we support evidence-based policies, and most of all to inspire us at a time of this geopolitical craziness and why we must continue to persist,” Dhruv Kazi, a cardiologist and health economist at UCSF, who opened the daylong event.

Rising cost of global health care

Global health-care spending is so massive due to several key factors, Jha told the audience: the unprecedented rapid expansion of people moving into the middle class and the rise in treatments, drugs and medical technologies.

And while these are all positive movements, he said, as the world becomes more interdependent, it “behooves us to act” quickly so that health coverage and quality keep up.

At the end of 2016 there were 3.2 billion people in the global middle class; on average 160 million will join the middle class annually for the next five years, heavily concentrated in Asia.

So the two goals of universal health care should be financial protection and improved health.

But Jha noted that while 90 percent of China’s 1.4 billion people are covered by its national health care system, some 18 percent of Chinese are still thrown into poverty by the incidence of catastrophic health spending above and beyond what the government provides. That is nearly 8 percent higher than the global incidence of catastrophic spending, which stands at 11.7 percent.

India, by contrast, does not have a universal health-care system and only 20 percent of it 1.3 billion people have some form of health insurance. But it also has a 17-percent incidence of catastrophic health spending.

“Catastrophic payment incidence cannot be inferred from the fraction of the population covered by health insurance schemes or public health services,” Jha said, quoting a recent Lancet study.

It stands to reason that the health outcomes of those in countries with universal health care should have improved. But most studies show that that is not the case; the reason?  The quality just isn’t there.

Unsafe medical care top cause of deaths

Nearly 43 million injuries are caused in hospitals each year around the world, leading to 23 million years of healthy living that is lost among the world’s population.

“Unsafe medical care is probably one of the top 10 causes of death and disability in the world,” Jha said.

Jha wondered if quality of care isn’t a bigger problem than access to care.  For example, in one of India’s poorer rural states, Madhya Pradesh, there are 11 health-care providers within walking distance of every village, a fairly large number of private providers.

“Yet half of them have no formal training, they didn’t go to any school but they call themselves doctors,” Jha said.

And in the capital of India, New Delhi, public-sector physicians who are well trained are so overworked they spend an average of 2.5 minutes and ask one question per patient.

Ideally, universal health care must be effective and consistent with best professional practices while meeting the needs of the individual patient.

“Global health policy leaders have made universal health coverage an overarching priority.  This is a good thing.  But in order for UHC to improve the health of the world’s poor, we need to ensure people get good care. And that is the biggest challenge of all.”

 

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Co-sponsored by the Asia Health Policy Program and the Southeast Asia Program

Achieving universal health coverage is one of the UN's Social Development Goals. The four countries in the lower Mekong region, Thailand, Vietnam, Laos, and Cambodia, have made good progress on the expansion of health insurance coverage. However, the statistics on how many people are covered and protected could be misleading, especially for vulnerable populations more likely to be left out. Using data from national surveys, a cross-country analysis shows the situation regarding health service access and health care payments among vulnerable populations in the four countries. Conditions and trends in health care utilization, and health payments and their impact on vulnerable populations will be reviewed and linked to policy implications. Pitfalls and successes in a region marked by diversity and unequal opportunity will also be explored.

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Dr. Piya Hanvoravongchai teaches health systems and health economics at Chulalongkorn University in Thailand. He is also a co-director of the Equity Initiative in Southeast Asia and a member of the Strategic Technical Advisory Committee of the Asia Pacific Observatory on Health Systems and Policies.

Piya Hanvoravongchai Faculty of Medicine, Chulalongkorn University, Bangkok
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Abstract: Clay fired bricks are a primary building material used in the rapidly expanding construction sector across South Asia. These bricks are primarily manufactured by small enterprises using inefficient, highly polluting coal-fired kilns. The black carbon and the greenhouse gases emitted by brick kilns across South Asia is comparable to the global radiative forcing of the entire US passenger car fleet. The pollution generated by these brick kilns also affect human health. In Dhaka, Bangladesh brick kilns contribute 40% of the ambient particulate matter during winter and are estimated to result in 5000 adult deaths each year. In addition, the coercive collection of topsoil as part of clay mining undermines agricultural productivity in settings of high poverty and malnutrition.

This talk will discuss why bricks are manufactured in Bangladesh using an approach that is so damaging to the environment and to public health. It will explore combined technical, financial and political strategies to transform the sector.

Speaker bio:  Prof. Luby studied philosophy and earned a Bachelor of Arts summa cum laude from Creighton University. Prof. Luby earned his medical degree from the University of Texas Southwestern Medical School at Dallas and completed his residency in internal medicine at the University of Rochester-Strong Memorial Hospital. He studied epidemiology and preventive medicine at the Centers for Disease Control and Prevention.

Prof. Luby's former positions include leading the Epidemiology Unit of the Community Health Sciences Department at the Aga Khan University in Karachi, Pakistan for 5 years and working as a Medical Epidemiologist in the Foodborne and Diarrheal Diseases Branch of the Centers for Disease Control and Prevention exploring causes and prevention of diarrheal disease in settings where diarrhea is a leading cause of childhood death.  Immediately prior to his current appointment, Prof. Luby served for 8 years at the International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b), where he directed the Centre for Communicable Diseases. Prof. Luby was seconded from the US Centers for Disease Control and Prevention (CDC) and was the Country Director for CDC in Bangladesh.

During his over 20 years of public health work in low income countries, Prof. Luby frequently encountered political and governance difficulties undermining efforts to improve public health. His work at FSI engages him with a community of scholars who provide ideas and approaches to understand and address these critical barriers.

Stephen Luby Professor of Medicine Stanford University
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