The recent terrorism attacks on the United States offer an illustrative case study for the safety and security of nuclear installations. This paper will specifically detail America's readiness to respond to potential incidents involving high-level nuclear waste and spent nuclear fuel. The presentation will suggest procedures relative to agencies that will be planning for these shipments and potential attacks against them. Additional aspects will be addressed concerning the training of the shipment corridor states where these tens of thousands of highly radioactive cargos will transverse over the forthcoming decades.