In this session of the Shorenstein APARC Corporate Affiliate Visiting Fellows Research Presentations, the following will be presented:

Minoru Aosaki, "Banking System and Sovereign Risk in Japan"

After the financial crisis of 2008, European financial markets have experienced sharp increases of sovereign risk. This adversely affected the solvency of banking institutions as they suffered losses from their sovereign holdings and deterioration in their funding conditions. Meanwhile, Japan's sovereign market remained stable, but market participants were cautious as the country’s debt-to-GDP ratio is the highest in the world, and its banking sector holds as much as 44% of domestic sovereign debt. The question is how Japanese policy makers should address the sovereign risk in the banking system. In pursuit of this question, Aosaki compares the market environment in Japan and the Euro Area, examining the reasons banks hold sovereign bonds and the channels that connect sovereign risk with the banking system.

Prashant Pandya, "Cell-based Therapies -- Current Trends and Future Prospects"

Stem cells have been the subject of considerable excitement and debate over the last decade. Stem cell therapy is emerging as a potentially revolutionary new way to treat disease and injury, with wide-ranging medical benefits. Stem cell research provides the opportunity to advance our understanding of human biology and treatment of various diseases. In Pandya’s research, he shares his experience about major challenges related to the commercial development of stem cell therapies and key technology drivers. This research is based on consultations with several prestigious regulatory agencies—including the U.S. Food and Drug Administration, European Medicines Agency, and Therapeutic Goods Administration of Australia—as well as interviews with 45 CEOs and senior scientists of large and small biotech companies and professors from leading universities across five countries. Pandya’s research reveals that there are many intriguing aspects of stem cells still remaining to be elucidated. Stem cells have the potential to treat an enormous range of diseases and conditions that plague millions of people and offer exciting promise for future therapies. But significant technical hurdles remain that will only be overcome through years of intensive research, and successful commercialization of cell-based therapies requires more than proving safety and efficacy to regulators. Ultimately the therapy must be commercially viable.

Ramnath Ramanathan, "Designing Toxicology Studies for Small Interfering Ribo Nucleic Acid"

The field of medicine has improved drastically over the period of time. Medical treatment has evolved from using plant extracts to chemical drugs to stem cell and gene therapies. Discovery of small interfering Ribo Nucleic Acid (siRNA) was one of the most important recent breakthroughs in the field of medicine. This was due to siRNA’s capability of posttranscriptional gene silencing by destruction of mRNA and thereby reducing the protein synthesis. Though the efficacy studies conducted in vitro and in animal models are promising, there have also been circumstances where there were adverse effects including mortality of animals treated with siRNA. Since RNA interference is a relatively new technique, it is very important to understand the toxicity involved before using it as a therapy. For this purpose, toxicology studies have to be designed in order to address all questions on the safety aspects of siRNA. In addition to the traditional toxicity studies, several other tests will have to be conducted. These additional studies will have to address issues specific to siRNA therapy such as immune activation, formation of tetraplex DNA, down regulation of non-target mRNA, interaction with cellular proteins, etc. Through Ramanathan’s work, he has designed a battery of toxicology studies to understand the side effects so that only relatively safe therapy is tried on humans during clinical trials. Ramanathan will present his findings.

Karl Eikenberry is the Payne Distinguished Lecturer at the Freeman Spogli Institute for International Studies. Within FSI he is an affiliated faculty member with the Center on Democracy, Development, and the Rule of Law (CDDRL) and the Center for International Security and Cooperation (CISAC), and an affiliated researcher with the Europe Center. Before coming to Stanford, he served as U.S. Ambassador to Afghanistan from May 2009 to July 2011, where he led the civilian side of the surge directed by President Obama to reverse Taliban momentum and help set the conditions for transition to full Afghan sovereignty.

Prior to his appointment as Chief of Mission in Kabul, Ambassador Eikenberry had a 35-year career with the U.S. Army, retiring with the rank of Lieutenant General in 2009.  His operational posts include service in the continental U.S., Hawaii, Korea, Italy, and Afghanistan, where he served as Commander of the American-led Coalition Forces from 2005-2007.

Ambassador Eikenberry also served in various political-military positions, including service as Deputy Chairman of the North Atlantic Treaty Organization (NATO) Military Committee in Brussels.

His military awards include the Defense Distinguished and Superior Service Medals, Legion of Merit, Bronze Star, Ranger Tab, Combat and Expert Infantryman badges, and master parachutist wings. He has received numerous civilian awards as well.

Amb. Eikenberry is a graduate of the U.S. Military Academy, holds master's degrees from Harvard University in East Asian Studies and Stanford University in Political Science, and was a National Security Fellow at the Kennedy School of Government at Harvard.

He is a trustee of the International Institute for Strategic Studies and a member of the Council on Foreign Relations and the Council of American Ambassadors. He recently received the George F. Kennan Award for Distinguished Public Service from the National Committee on American Foreign Policy. He has published numerous articles on U.S. military training, tactics, and strategy and on Chinese military history and Asia-Pacific security issues.

Abstract:  

The "spirit of democracy" has recently been undermined in several African countries as authoritarian methods have been the preferred approach. In countries such as Kenya, Zimbabwe, Cote d'Ivoire, Niger and Gabon political change has come through the following means; military interventions ousting former presidents clinging to power after their terms; violently repressed popular unrests leading to power-sharing solutions, or former presidents being replaced by their sons. In few countries such as Guinea, free elections were organized after several decades of dictatorship.   

In this seminar, CDDRL Post-Doctoral Fellow Landry Signé will examine what makes certain countries adopt and consolidate liberal or electoral democracies when others stay authoritarian - whether competitive, hegemonic or politically closed. Signé will analyze the transformations of political regimes and democratization in the 48 Sub-Saharan African countries over the two last decades contrasting various political trajectories, comparing results between successful and failed countries, and exploring the conditions that create, maintain and sustain democracies. 

Speaker Bio:  

Landry Signé is a recipient of the 2011-2013 Banting Postdoctoral Fellowship Award from the Social Sciences and Humanities Research Council of Canada hosted by the Center on Democracy, Development and the Rule of Law at Stanford University. He is working on a project entitled “The Efficiency of the Political Responses to the Global Financial and Economic Crisis in Africa: Does the Political Regime and Economic Structure Matter?”. He completed his PhD in Political Science (2010), with the Award of Excellence, at the University of Montreal, and has been bestowed the Award for Best International PhD Dissertation of 2011 by the Center for International Studies and Research (CÉRIUM). His dissertation is entitled “Political Innovation: The Role of the International, Regional and National Actors in the Economic Development of Africa”. 

Prior to joining the CDDRL, Dr. Signé was a visiting scholar at the Stanford Center on African Studies, lecturer on Emerging African Markets: Strategies, Investments and Government Affairs at the Stanford Continuing Studies, founding president of a Canadian corporation specialized in public affairs and business development, part-time professor and lecturer in political science at Ottawa University and the University of Montreal, administrator at the United Nations Association of Canada-Greater Montréal, and president of the Political Commission of Montreal-CJ. He has worked or interned at the United Nations Department of Political Affairs, the Senate of France, the National Assembly of Cameroon, and the French Distributor, Casino Group. He studied Political Science, International Relations, Communication and Business at the University of Montreal, Lyon 3 University, Sciences Po Paris, Sandar Institute, Stanford Continuing Studies, and McGill University.

This talk will address a primary foreign policy challenge for independent Ukraine which has been to strike a proper balance between its relations with the West and those with Russia.  Today, democratic backsliding is upsetting the balance, which will undermine President Yanukovych’s ability to achieve his professed foreign policy aims.


Steven Pifer is a senior fellow at the Brookings Institution’s Center on the United States and Europe and director of the Brookings Arms Control Initiative.  He focuses on nuclear arms control, Russia and Ukraine.  He has offered commentary on these issues on CNN, Fox News, BBC, National Public Radio and VOA, and his articles have run in the International Herald Tribune, New York Times, Washington Post and Moscow Times, among others.

A retired Foreign Service officer, his more than 25 years with the State Department focused on U.S. relations with the former Soviet Union and Europe, as well as arms control and security issues.  He served as deputy assistant secretary of state in the Bureau of European and Eurasian Affairs with responsibilities for Russia and Ukraine (2001-2004), U.S. ambassador to Ukraine (1998-2000), and special assistant to the president and senior director for Russia, Ukraine and Eurasia on the National Security Council (1996-1997).

His publications include “Ukraine’s Perilous Balancing Act,” Current History (March 2012), “NATO, Nuclear Weapons and Arms Control,” Brookings Arms Control Series (July 2011); “The Next Round:  The United States and Nuclear Arms Reductions After New START,” Brookings Arms Control Series (November 2010); “Ukraine’s Geopolitical Choice, 2009,” Eurasian Geography and Economics (July 2009); and “Reversing the Decline:  An Agenda for U.S.-Russian Relations in 2009,” Brookings Foreign Policy Paper (January 2009).

Ambassador Pifer is a 1976 graduate of Stanford University with a B.A. in Economics.  He is a member of the Council on Foreign Relations. 

Co-sponsored by the Center for Russian, East European, and Eurasian Studies