Climate change is intensifying droughts and threatening water security worldwide, particularly in arid and semi-arid regions. Israel’s innovative response has been to integrate large-scale desalination into its water supply and climate resilience strategy, recently constructing the Reverse Water Carrier, a pioneering project that conveys desalinated seawater from the Mediterranean inland to Lake Kinneret (Sea of Galilee). This study examines the objectives, rationale, and feasibility of this system as a model for climate-resilient water management. Using a qualitative case study approach, it evaluates the project across four dimensions: water security, environmental sustainability, economic feasibility and regional cooperation. Data were drawn from policy documents, expert interviews, and government reports. The analysis finds that replenishing the Kinneret with surplus desalinated water enhances national water reliability, reduces salinity, stabilizes agricultural production, and provides a critical emergency reserve, while introducing manageable energy and ecological trade-offs. Although long-term sustainability will depend on continued efficiency improvements and adaptive management, Israel’s experience demonstrates how inter-basin desalination transfers can strengthen water security and offer a replicable framework for other regions confronting climate-induced scarcity.