The purpose of this text is to present the proposals of drug policy reform elaborated by the Beckley Foundation for the Government of Guatemala, as part of the agreement set between these two bodies. Amanda Feilding was invited by President Otto Pérez Molina to establish a Beckley Foundation Latin American Chapter in Guatemala in July 2012, and was requested to produce a rigorous, evidence-based analysis of the impact of current prohibitionist drug policies on Guatemala and the wider region. The Beckley Foundation was also asked to develop and suggest a series of alternative drug policy options. The proposals were submitted in January 2013 as a contribution to the development of drug policies focused on public health, crime prevention, and social harm-reduction. While the Foundation’s proposals have been specifically tailored for Guatemala, elements of our research can serve as a model for other countries in the region and the hemisphere, and may nurture fruitful discussion and negotiation.