Context: Fetuin-A inhibits the insulin receptor in vitro. Higher serum fetuin-A concentrations are associated with type 2 diabetes longitudinally and greater adiposity in cross-sectional analyses. Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown.
Objective: To determine the association of fetuin-A levels with changes in body composition over 5 yr.
Study Design: Observational cohort study nested in the Health Aging and Body Composition Study.