"In terms of geo-politics, the most difficult and most challenging part of the world in this era, particularly in the aftermath of 9/11, is the broader Middle East," said Zalmay Khalilzad, in a 2010 Payne Distinguished Lecture, "The Struggle for the Broader Middle East: Where We Are and Where We Need to Go." A native of Afghanistan, Khalilzad served as U.S. Ambassador to the United Nations, Iraq, and Afghanistan, and as a senior White House, Defense, and State Department Advisor.

Tracing the dynamic interplay of national, regional, and international forces, he set out five major issues likely to shape the future of the region:

1. The challenge of militant Islam, resulting from an ongoing crisis of civilization within a once powerful, innovative, and dynamic Islamic world.
2. Regional disputes, including the Arab-Israeli conflict, the Afghanistan-Pakistan border dispute, and ongoing Indian-Pakistani disputes.  Terming the Arab-Israeli conflict an important shaping factor, Khalilzad said that circumstances were not ready for a settlement.  "Israel wants a process without an outcome and the Palestinians want an outcome without a process," he said.
3. Rivalry for regional hegemony, including the rivalry between Shia and Sunni Islam and Iran's quest to obtain a nuclear weapon.  In the struggle over Iran's nuclear program, he said, is the potential for a wider regional conflict. Israel could attack Iran's facilities, destabilizing the region, and over the long term, a nuclear Iran would threaten Israel and provoke both state and sub-state proliferation.
4. Broader political and economic development and democratization efforts. The region's population is growing rapidly, but the educational system prepares the young poorly for the modern world and job prospects are limited, creating discontent and the danger of internal instability.
5. Extra regional factors, including U.S. policy. Setting a July 2011 timeline to withdraw troops from Afghanistan has had unintended consequences, he said, including increased corruption, as people seek to maximize access to resources now. In Iraq, institution building has been effective, the resource base is there for a power-sharing formula, and Iraq can do quite well. The pledge of U.S. troop withdrawals this summer, however, has led Iraqis to think "we are on our way out" and led them to look to regional actors for support, adding to polarization.

The region remains vitally important, he concluded, given the challenges emanating from it.  "A civilization crisis takes a long time to work itself out," he said, "and although the world is affected by it, we can influence it to a degree, but we have to do so without undermining the more moderate and secular forces for the good."