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Biosecurity

Recent Scholarly Publications

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On Defining Global Catastrophic Biological Risks

July 2017

The Johns Hopkins Center for Health Security has formulated an encompassing working definition of global catastrophic biological risks (GCBRs) that reflects diverse sources of risk and mechanisms...

A More Systematic Approach to Biological Risk

December 2015

Management of emerging risks in life science and technology requires new leadership and a sober assessment of the legacy of Asilomar.

How likely is it that biological agents will be used deliberately to cause widespread harm?

December 2015

The fact that biological weapons have never been used—at least in recent history—is not sufficient reason to dismiss concerns that terrorists or nations could acquire and use dangerous pathogens as...

New Game, New Rules: Limiting the Risks of Biological Engineering

September 2015

In an article published by the Council on Foreign Relations' Foreign Affairs magazine, David Relman and Marc Lipsitch examine recent advances in biological engineering as well as lapses in...

Gain-of-function experiments: time for a real debate

December 2014

According to the WHO, dual use research of concern (DURC) is “life sciences research that is intended for benefit, but which might easily be misapplied to do harm”.

The Increasingly Compelling Moral Responsibilities of Life Scientists

March 2013

First paragraph of article:Many of my colleagues and fellow investigators in the life sciences were surprised in late 2011 to hear about the deliberate laboratory manipulation of highly pathogenic...

The Next Catastrophe: Reducing Our Vulnerabilities to Natural, Industrial, and Terrorist Disasters

December 2011

Charles Perrow is famous worldwide for his ideas about normal accidents, the notion that multiple and unexpected failures--catastrophes waiting to happen--are built into our society's complex...

Health Outcomes and Costs of Community Mitigation Strategies for an Influenza Pandemic in the United States

December 2010

Background. The optimal community-level approach to control pandemic influenza is unknown. Methods.

Microbial threat lists: obstacles in the quest for biosecurity?

February 2010

Abstract: Anxiety about threats from the microbial world and about the deliberate misuse of microorganisms has led to efforts to define and control these dangers using lists and regulations.

Health outcomes and costs of community mitigation strategies for an influenza pandemic in the United States.

January 2010

BACKGROUND: The optimal community-level approach to control pandemic influenza is unknown.

Can an Infectious Disease Genomics Project ‘Predict and Prevent’ the next Pandemic?

December 2009

The world of genomics is transforming medicine, and is likely to influence the future development of new drugs, diagnostics, and vaccines.

Pandemic Influenza and the Globalization of Public Health

December 2009

When one can circle the globe in less than the time of incubation of most infectious pathogens, it is clear every country relies to some extent on the health systems of other countries to prevent...

Effectiveness and Cost-Effectiveness of Vaccination Against Pandemic Influenza (H1N1) 2009

December 2009

Background: Decisions on the timing and extent of vaccination against pandemic (H1N1) 2009 virus are complex.

Effectiveness and Cost-Effectiveness of Expanded Antiviral Prophylaxis and Adjuvanted Vaccination Strategies for an Influenza A (H5N1) Pandemic

December 2009

Background: The pandemic potential of influenza A (H5N1) virus is a prominent public health concern of the 21st century.

Safety and Efficacy of Extended-Duration Antiviral Chemoprophylaxis Against Pandemic and Seasonal Influenza

October 2009

Background: Neuraminidase inhibitors (NAIs) are stockpiled internationally for extended use in an influenza pandemic.

Decision Framework for Coordinating Bioterrorism Planning, A: Lessons from the BioNet Program

January 2009

Background: Effective disaster preparedness requires coordination across multiple organizations.

Global Welfare Regimes: A Cluster Analysis

January 2009

This paper tests the claim that a small number of distinct „welfare regimes,combining institutional patterns and social welfare outcomes, can be identifiedacross the developing world.

Strategies for Combating Bioterrorism

December 2008

Modeling the Incubation Period of Inhalational Anthrax

July 2008

Ever since the pioneering work of Philip Sartwell, the incubation period distribution for infectious diseases is most often modeled using a lognormal distribution.

Modeling the Logistics of Response to Anthrax Bioterrorism

March 2008

Background: A bioterrorism attack with an agent such as anthrax will require rapid deployment of medical and pharmaceutical supplies to exposed individuals.

An Ounce of Prevention Is Worth a Pound of Cure: Improving Communication to Reduce Mortality During Bioterrorism Responses

March 2008

OBJECTIVE: To identify communication needs and evaluate the effectiveness of alternative communication strategies for bioterrorism responses.

Crisis Preparedness: Asia and the Global Governance of Epidemics

June 2007

Throughout history, nations have waged war against epidemics, from bubonic plague to pulmonary tuberculosis.

Analyzing the Control of Mosquito-Borne Diseases by a Dominant Lethal Genetic System

May 2007

Motivated by the failure of current methods to control dengue fever, we formulate a mathematical model to assess the impact on the spread of a mosquito-borne viral disease of a strategy that...

Edge of Disaster, The: Rebuilding a Resilient Nation

February 2007

We have learned little from the cataclysms of September 11 and Hurricane Katrina. When it comes to catastrophe, America is living on borrowed time--and squandering it.

People

1 RSD13 085 0052a 001 David Relman Senior Fellow Professor, Medicine, Professor, Microbiology and Immunology
endy Drew Endy Assistant Professor, Bioengineering